Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.
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Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosisMitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems.Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer AgentsGold compounds as therapeutic agents for human diseasesGold(I) complexes of 9-deazahypoxanthine as selective antitumor and anti-inflammatory agentsGold (I) N-heterocyclic carbene complex inhibits mouse melanoma growth by p53 upregulation.Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions.Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands.Organometallic anticancer compoundsLuminescent di- and polynuclear organometallic gold(I)-metal (Au2, {Au2Ag}n and {Au2Cu}n) compounds containing bidentate phosphanes as active antimicrobial agents.A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging.On the mechanism and rate of gold incorporation into thiol-dependent flavoreductasesBiological Screening of Newly Synthesized BIAN N-Heterocyclic Gold Carbene Complexes in Zebrafish Embryos.Targeting Antioxidant Pathways with Ferrocenylated N-Heterocyclic Carbene Supported Gold(I) Complexes in A549 Lung Cancer Cells.Versatile synthesis of cationic N-heterocyclic carbene-gold(i) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium-gold anticancer agents.Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.The medicinal applications of imidazolium carbene-metal complexes.N-Heterocyclic Carbene-Gold(I) Complexes Conjugated to a Leukemia-Specific DNA Aptamer for Targeted Drug DeliveryCopper, gold and silver compounds as potential new anti-tumor metallodrugs.Therapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatment.Advances in metal-carbene complexes as potent anti-cancer agents.A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds.Metallomics insights into the programmed cell death induced by metal-based anticancer compounds.Benzyl-substituted metallocarbene antibiotics and anticancer drugs.Mutual action of anticancer and antiparasitic drugs: are there any shared targets?Chemical biology of anticancer gold(III) and gold(I) complexes.Porphyrins Conjugated with Peripheral Thiolato Gold(I) Complexes for Enhanced Photodynamic Therapy.A multi-functional PEGylated gold(iii) compound: potent anti-cancer properties and self-assembly into nanostructures for drug co-deliveryLuminescent bioactive NHC-metal complexes to bring light into cells.Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework.Palladacycle promoted base controlled regio- and enantioselective hydrophosphination of 2-pyridylacrylate/amide and the cytotoxicity of their gold complexes.Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents.Synthesis, characterization, cytotoxic and antitubercular activities of new gold(I) and gold(III) complexes containing ligands derived from carbohydrates.Lipophilicity-dependent ruthenium N-heterocyclic carbene complexes as potential anticancer agents.5-diphenylacetamido-indirubin-3'-oxime as a novel mitochondria-targeting agent with anti-leukemic activities.Synthesis, characterization and urease inhibition, in vitro anticancer and antileishmanial studies of Ni(II) complexes with N,N,N'-trisubstituted thioureas.A cancer-targeted nanosystem for delivery of gold(III) complexes: enhanced selectivity and apoptosis-inducing efficacy of a gold(III) porphyrin complex.Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes.Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.
P2860
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P2860
Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Mitochondria-targeted chemotherapeutics: the rational design of gold
@nl
Mitochondria-targeted chemothe ...... enols in preference to thiols.
@ast
Mitochondria-targeted chemothe ...... enols in preference to thiols.
@en
type
label
Mitochondria-targeted chemotherapeutics: the rational design of gold
@nl
Mitochondria-targeted chemothe ...... enols in preference to thiols.
@ast
Mitochondria-targeted chemothe ...... enols in preference to thiols.
@en
prefLabel
Mitochondria-targeted chemotherapeutics: the rational design of gold
@nl
Mitochondria-targeted chemothe ...... enols in preference to thiols.
@ast
Mitochondria-targeted chemothe ...... enols in preference to thiols.
@en
P50
P921
P356
P1476
Mitochondria-targeted chemothe ...... lenols in preference to thiols
@en
P2093
James L Hickey
Rasha A Ruhayel
P304
12570-12571
P356
10.1021/JA804027J
P407
P577
2008-08-26T00:00:00Z