Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes - Test2 - elhamkhani - TriplyDB

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

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Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1 Hexosamines, insulin resistance, and the complications of diabetes: current status.Adipocyte extracellular matrix composition, dynamics and role in obesity Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer O-GlcNAcylation: a bridge between glucose and cell differentiation Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology O-GlcNAcylation and Metabolic Reprograming in Cancer Posttranslational regulation of Akt in human cancer Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach The hexosamine signaling pathway: deciphering the "O-GlcNAc code"Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cells Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose.O-GlcNAc regulates FoxO activation in response to glucose.O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice.Identification of secret agent as the O-GlcNAc transferase that participates in Plum pox virus infection O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development.The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs.The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis Regulation of Dauer formation by O-GlcNAcylation in Caenorhabditis elegans.The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy.Toxic effects of hyperglycemia are mediated by the hexosamine signaling pathway and o-linked glycosylation in early mouse embryos.Quantitative secretome and glycome of primary human adipocytes during insulin resistance.

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P2860

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

http://www.wikidata.org/entity/Q34024499

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2002 nî lūn-bûn

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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2002 թվականի ապրիլին հրատարակված գիտական հոդված

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2002年の論文

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Elevated nucleocytoplasmic gly ...... ctivation in 3T3-L1 adipocytes

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Elevated nucleocytoplasmic gly ...... ctivation in 3T3-L1 adipocytes

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Elevated nucleocytoplasmic gly ...... ctivation in 3T3-L1 adipocytes

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Elevated nucleocytoplasmic gly ...... ctivation in 3T3-L1 adipocytes

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Elevated nucleocytoplasmic gly ...... ctivation in 3T3-L1 adipocytes

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Elevated nucleocytoplasmic gly ...... ctivation in 3T3-L1 adipocytes

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Proceedings of the National Academy of Sciences of the United States of America

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Elevated nucleocytoplasmic gly ...... ctivation in 3T3-L1 adipocytes

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Gerald W Hart

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Keith Vosseller

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Lance Wells

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M Daniel Lane

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P2860

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Biochemistry and molecular cell biology of diabetic complications

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10.1073/PNAS.072072399

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