PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. - Test2 - elhamkhani - TriplyDB

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

http://www.wikidata.org/entity/Q34038299

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GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation.The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity The metal face of protein tyrosine phosphatase 1B Role of Fas-associated death domain-containing protein (FADD) phosphorylation in regulating glucose homeostasis: from proteomic discovery to physiological validation Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone.Targeting PTPs with small molecule inhibitors in cancer treatment Discovery of novel PTP1B inhibitors with antihyperglycemic activity.Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice Molecular mechanism of insulin resistance in obesity and type 2 diabetes.Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats.Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.Protein tyrosine phosphatases as potential therapeutic targets.Prelamin A and lamin A appear to be dispensable in the nuclear lamina.Molecular mechanisms of insulin resistance.A HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities.Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling Specific reduction of hepatic glucose 6-phosphate transporter-1 ameliorates diabetes while avoiding complications of glycogen storage disease.Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats.PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity.Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents.Protein-tyrosine phosphatase 1B substrates and metabolic regulation The potential of antisense as a CNS therapeutic.Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants.Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice.Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins.Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice.Molecular mechanism of angiotensin II-induced insulin resistance in aortic vascular smooth muscle cells: roles of Protein Tyrosine Phosphatase-1B.Recent advances in protein tyrosine phosphatase 1B inhibitors.Glucose Uptake Activities of Bis (2, 3-Dibromo-4, 5-Dihydroxybenzyl) Ether, a Novel Marine Natural Product from Red Alga Odonthaliacorymbifera with Protein Tyrosine Phosphatase 1B Inhibition, In Vitro and In Vivo

P2860

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P2860

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

http://www.wikidata.org/entity/Q34038299

description

2002 nî lūn-bûn

@nan

2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի օգոստոսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

@ast

PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

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PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

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type

label

PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

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PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

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PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

@nl

prefLabel

PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

@ast

PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

@en

PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

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Proceedings of the National Academy of Sciences of the United States of America

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PTP1B antisense oligonucleotid ...... sensitivity in diabetic mice.

@en

P2093

Bradley A Zinker

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Brett P Monia

http://www.w3.org/2001/XMLSchema#string

Cristina M Rondinone

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Denise Wilcox

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James M Trevillyan

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Jeffrey F Waring

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Jill E Clampit

http://www.w3.org/2001/XMLSchema#string

Leigh Frost

http://www.w3.org/2001/XMLSchema#string

Madeline Butler

http://www.w3.org/2001/XMLSchema#string

Michael R Jirousek

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P2860

Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

Mechanism of activation of protein kinase B by insulin and IGF-1

Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

The IRS-signalling system: a network of docking proteins that mediate insulin action

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

Banting lecture 1988. Role of insulin resistance in human disease

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.

Novel mechanisms for antisense-mediated regulation of gene expression.

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11357-11362

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scholarly article

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10.1073/PNAS.142298199

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P433

17

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99

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2002-08-08T00:00:00Z

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11216687

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12169659

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123261

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