Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. - Test2 - elhamkhani - TriplyDB

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

http://www.wikidata.org/entity/Q34040084

about

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans Role of FTO in Adipocyte Development and Function: Recent Insights Obesity genetics in mouse and human: back and forth, and back again Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus.Complex Relationship between Obesity and the Fat Mass and Obesity Locus FTO influences adipogenesis by regulating mitotic clonal expansion N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases.FTO knockdown in rat ventromedial hypothalamus does not affect energy balance Associations between FTO genotype and total energy and macronutrient intake in adults: a systematic review and meta-analysis.The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane.Hypothalamic Leptin Resistance: From BBB to BBSome.A Potential Contributory Role for Ciliary Dysfunction in the 16p11.2 600 kb BP4-BP5 Pathology FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients.Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.Hypomorphism of Fto and Rpgrip1l causes obesity in mice.Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents.Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia.Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome.The Association of FTO SNP rs9939609 with Weight Gain at University.The Leptin Receptor Complex: Heavier Than Expected?The molecular motor Myosin Va interacts with the cilia-centrosomal protein RPGRIP1L.Determination of the half-life of circulating leptin in the mouse.Genetic strategies to understand physiological pathways regulating body weight.FTO is necessary for the induction of leptin resistance by high-fat feeding.Metabolic regulation and energy homeostasis through the primary Cilium.Discussing the putative role of obesity-associated genes in the etiopathogenesis of eating disorders.Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies.Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.Mechanisms of Type 2 Diabetes Risk Loci.The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.Mutations in ARMC9, which Encodes a Basal Body Protein, Cause Joubert Syndrome in Humans and Ciliopathy Phenotypes in Zebrafish.Leptin signalling pathways in hypothalamic neurons.The cilium: a cellular antenna with an influence on obesity risk.FTO gene variants are associated with growth and carcass traits in cattle.Cilia and Obesity.The RNA Modification N6-methyladenosine and Its Implications in Human Disease.The fat mass and obesity-associated (FTO) gene variant rs9939609 predicts long-term incidence of cardiovascular disease and related death independent of the traditional risk factors.

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P2860

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

http://www.wikidata.org/entity/Q34040084

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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J.CMET.2014.04.009

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Cell Metabolism

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Hypomorphism for RPGRIP1L, a c ...... s increased adiposity in mice.

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Charles A Leduc

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Daniel A Doherty

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Diana R O'Day

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George Stratigopoulos

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Jayne F Martin Carli

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Liheng Wang

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Michael Rosenbaum

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Patricia Lanzano

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Rudolph L Leibel

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Wendy K Chung

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P2860

The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly

TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone

Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome

The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome

A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

Mutations in 3 genes (MKS3, CC2D2A and RPGRIP1L) cause COACH syndrome (Joubert syndrome with congenital hepatic fibrosis)

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies

Adult type 3 adenylyl cyclase-deficient mice are obese

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10.1016/J.CMET.2014.04.009

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