RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. - Test2 - elhamkhani - TriplyDB

RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

http://www.wikidata.org/entity/Q34040089

about

Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture How SUMOylation Fine-Tunes the Fanconi Anemia DNA Repair Pathway Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability Role of Deubiquitinating Enzymes in DNA Repair RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO SUMO-mediated regulation of DNA damage repair and responses Ubiquitylation, neddylation and the DNA damage response USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells.SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response.The role of ubiquitination and sumoylation in diabetic nephropathy.Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.Intrinsic disorder drives N-terminal ubiquitination by Ube2w Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.Deciphering the BRCA1 Tumor Suppressor Network.Identification of RNF168 as a PML nuclear body regulator MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168 Heterochromatic breaks move to the nuclear periphery to continue recombinational repair.SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.Sequential posttranslational modifications regulate PKC degradation.RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner Genetic evaluation of BRCA1 associated a complex genes with triple-negative breast cancer susceptibility in Chinese women.Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks.A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1.DNA damage emergency: cellular garbage disposal to the rescue?Decoding the SUMO signal.Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair.The SUMO system: a master organizer of nuclear protein assemblies.SUMO rules: regulatory concepts and their implication in neurologic functions.RNA splicing: a new player in the DNA damage response Spatiotemporal regulation of posttranslational modifications in the DNA damage response.Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.A high-yield double-purification proteomics strategy for the identification of SUMO sites.Chemical and semisynthetic approaches to study and target deubiquitinases.

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RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

http://www.wikidata.org/entity/Q34040089

description

2012 nî lūn-bûn

@nan

2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

@zh-hk

2012年論文

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2012年論文

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2012年论文

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name

RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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RNF4-dependent hybrid SUMO-ubi ...... BRCA1 to sites of DNA damage.

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SCISIGNAL.2003485

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Science Signaling

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RNF4-dependent hybrid SUMO-ubi ...... f BRCA1 to sites of DNA damage

@en

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Ajit Datta

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Catherine M Guzzo

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Roger A Greenberg

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Vibhor Gupta

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P2860

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription.

Purification and identification of endogenous polySUMO conjugates

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

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ra88

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10.1126/SCISIGNAL.2003485

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253

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5

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Michael J. Matunis

Christopher E. Berndsen

Cynthia Wolberger

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2012-12-04T00:00:00Z

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23211528

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4131685

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