Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
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Acute systemic DNA damage in youth does not impair immune defense with agingHallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsBuilding for the future: essential infrastructure for rodent ageing studiesDNA Damage Response in Hematopoietic Stem Cell Ageing"Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 DiabetesFinding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesSenescent intimal foam cells are deleterious at all stages of atherosclerosisAging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cellsSenescence associated macrophages and "macroph-aging": are they pieces of the same puzzle?Oncogenic senescence: a multi-functional perspective.A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC.Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factorsDirected elimination of senescent cells by inhibition of BCL-W and BCL-XLCellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.Senotherapy: growing old and staying young?Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans.Discovery of piperlongumine as a potential novel lead for the development of senolytic agents.Context-dependent effects of cellular senescence in cancer development.The Aging EpigenomeIncreased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis.Ageing and the pathogenesis of osteoarthritis.Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases.Elimination of p19(ARF)-expressing cells enhances pulmonary function in mice.Apoptotic transition of senescent cells accompanied with mitochondrial hyper-function.Robust, universal biomarker assay to detect senescent cells in biological specimens.Conserved and novel functions of programmed cellular senescence during vertebrate development.Cellular senescence in osteoarthritis pathology.Disease drivers of aging.Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging.New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463Quantitative Analysis of Cellular Senescence in Culture and In Vivo.Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo.Oxidative stress in mesenchymal stem cell senescence: regulation by coding and non-coding RNAs.p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.Bcl-2 proteins in development, health, and disease of the hematopoietic system.Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway.Renal Aging: Causes and Consequences.
P2860
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P2860
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
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2015 nî lūn-bûn
@nan
2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@ast
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@en
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@nl
type
label
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@ast
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@en
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@nl
prefLabel
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@ast
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@en
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@nl
P2093
P2860
P356
P1433
P1476
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
@en
P2093
Aimin Meng
Daohong Zhou
Jianhui Chang
Judith Campisi
Kimberly Krager
Krishnamurthy Janakiraman
Lijian Shao
Martin Hauer-Jensen
Nukhet Aykin-Burns
Remi-Martin Laberge
P2860
P2888
P356
10.1038/NM.4010
P407
P577
2015-12-14T00:00:00Z