Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors - Test2 - elhamkhani - TriplyDB

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

http://www.wikidata.org/entity/Q34045737

about

Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules Small molecule compounds that induce cellular senescence Aging and adipose tissue: potential interventions for diabetes and regenerative medicine Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells.A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC.Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.Senotherapy: growing old and staying young?Discovery of piperlongumine as a potential novel lead for the development of senolytic agents.Satellite Cells in Muscular Dystrophy - Lost in Polarity.Pharmacological Strategies to Retard Cardiovascular Aging Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes.Strategies and Challenges in Clinical Trials Targeting Human Aging.Cellular senescence mediates fibrotic pulmonary disease Cellular senescence in osteoarthritis pathology.Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging.New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 Quantitative Analysis of Cellular Senescence in Culture and In Vivo.IPF lung fibroblasts have a senescent phenotype.Targeting cellular senescence prevents age-related bone loss in mice.Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo.Novel strategies for anti-aging drug discovery.Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents.Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?Fate of microglia during HIV-1 infection: From activation to senescence?Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty.Cellular Senescence: A Translational Perspective.Energetic interventions for healthspan and resiliency with aging.The Clinical Potential of Senolytic Drugs.Senescence in Health and Disease.Unbalanced Growth, Senescence and Aging.Proteostasis in cardiac health and disease.Systems modelling ageing: from single senescent cells to simple multi-cellular models.Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?Senescent cells: an emerging target for diseases of ageing.Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.Senescence in the aging process.Identification of HSP90 inhibitors as a novel class of senolytics.p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

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P2860

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

http://www.wikidata.org/entity/Q34045737

description

2015 nî lūn-bûn

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2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Identification of a novel seno ...... mily of anti-apoptotic factors

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type

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Identification of a novel seno ...... mily of anti-apoptotic factors

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Cory B Giles

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Heike Fuhrmann-Stroissnigg

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James L Kirkland

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Jonathan D Wren

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Kurt O Johnson

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Laura J Niedernhofer

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Michael B Stout

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Nino Giorgadze

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Paul D Robbins

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Tamar Pirtskhalava

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P2860

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

Targeting BCL2-Proteins for the Treatment of Solid Tumours

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

Aging, depot origin, and preadipocyte gene expression.

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.

BH3 mimetics: status of the field and new developments.

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428-435

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10.1111/ACEL.12445

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26711051

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4854923

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