The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.
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Human metapneumovirus M2-2 protein inhibits innate cellular signaling by targeting MAVSHemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1Induction of innate immunity and its perturbation by influenza virusesEvidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded ProteinInfluenza virus activation of the interferon systemThe N-terminal fragment of a PB2 subunit from the influenza A virus (A/Hong Kong/156/1997 H5N1) effectively inhibits RNP activity and viral replicationInnate immune induction and influenza protection elicited by a response-selective agonist of human C5aConvergent evolution of escape from hepaciviral antagonism in primatesPB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression.Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virionsInfluenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune ResponsesPhylogenetic Analysis and Functional Characterization of the Influenza A H5N1 PB2 Gene.Interplay between influenza A virus and host factors: targets for antiviral intervention.The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in MiceMultiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human CellsInhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy.An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo.Restored PB1-F2 in the 2009 pandemic H1N1 influenza virus has minimal effects in swine.Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potentialAsparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus.The C-Terminal Effector Domain of Non-Structural Protein 1 of Influenza A Virus Blocks IFN-β Production by Targeting TNF Receptor-Associated Factor 3The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I.Regulation of interferon-β by MAGI-1 and its interaction with influenza A virus NS1 protein with ESEV PBMNeurovirulence of H5N1 infection in ferrets is mediated by multifocal replication in distinct permissive neuronal cell regionsA single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivoGenetic Dissection of the Host Tropism of Human-Tropic Pathogens.Chicken cyclophilin A is an inhibitory factor to influenza virus replication.Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 proteinInfluenza A virus NS1 gene mutations F103L and M106I increase replication and virulence.Highly pathogenic H5N1 influenza A virus strains provoke heterogeneous IFN-α/β responses that distinctively affect viral propagation in human cells.High yield production of influenza virus in Madin Darby canine kidney (MDCK) cells with stable knockdown of IRF7The influenza virus protein PB1-F2 interacts with IKKβ and modulates NF-κB signalling.Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype.Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factorsThe ubiquitination of the influenza A virus PB1-F2 protein is crucial for its biological functionViral product trafficking to mitochondria, mechanisms and roles in pathogenesis.
P2860
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P2860
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
The PB2 subunit of the influen ...... expression of beta interferon.
@ast
The PB2 subunit of the influen ...... expression of beta interferon.
@en
The PB2 subunit of the influen ...... expression of beta interferon.
@nl
type
label
The PB2 subunit of the influen ...... expression of beta interferon.
@ast
The PB2 subunit of the influen ...... expression of beta interferon.
@en
The PB2 subunit of the influen ...... expression of beta interferon.
@nl
prefLabel
The PB2 subunit of the influen ...... expression of beta interferon.
@ast
The PB2 subunit of the influen ...... expression of beta interferon.
@en
The PB2 subunit of the influen ...... expression of beta interferon.
@nl
P2093
P2860
P50
P356
P1433
P1476
The PB2 subunit of the influen ...... expression of beta interferon.
@en
P2093
Amber W McCall
Katy M Graef
Simon M Carr
Yuk-Fai Lau
P2860
P304
P356
10.1128/JVI.00879-10
P407
P577
2010-06-10T00:00:00Z