Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication - Test2 - elhamkhani - TriplyDB

Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication

Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication

http://www.wikidata.org/entity/Q34055919

about

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity Mechanism of cancer cell death induced by depletion of an essential replication regulator Crystal structure of human CDC7 kinase in complex with its activator DBF4 Titration of four replication factors is essential for the Xenopus laevis midblastula transition Drf1-dependent kinase interacts with Claspin through a conserved protein motif.The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae.Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio.Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication.Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain Cell cycle regulation of DNA replication.Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts.Dbf4: the whole is greater than the sum of its parts Regulation of DNA Replication in Early Embryonic Cleavages.Roles of CDK and DDK in Genome Duplication and Maintenance: Meiotic Singularities.Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation.A synthetic human kinase can control cell cycle progression in budding yeast.Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition.Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts.Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition Cell Cycle Synchronization in Xenopus Egg Extracts.RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin.Suppression of targeting of Dbf4-dependent kinase to pre-replicative complex in G0 nuclei.Xenopus CDC7/DRF1 complex is required for the initiation of DNA replication.Maturation-associated Dbf4 expression is essential for mouse zygotic DNA replication.Cdc7 is an active kinase in human cancer cells undergoing replication stress.

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P2860

Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication

http://www.wikidata.org/entity/Q34055919

description

2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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type

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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Genes & Development

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Cdc7-Drf1 is a developmentally ...... of vertebrate DNA replication

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P2093

Johannes C Walter

http://www.w3.org/2001/XMLSchema#string

Tatsuro S Takahashi

http://www.w3.org/2001/XMLSchema#string

P2860

A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells

Drf1, a novel regulatory subunit for human Cdc7 kinase

Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7

A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases

Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication

mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p

A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication

DNA replication in eukaryotic cells

Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks

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2295-2300

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scholarly article

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10.1101/GAD.1339805

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19

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19

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2005-10-01T00:00:00Z

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7561424

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16204181

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1240038

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