P2Y nucleotide receptors: promise of therapeutic applications - Test2 - elhamkhani - TriplyDB

P2Y nucleotide receptors: promise of therapeutic applications

P2Y nucleotide receptors: promise of therapeutic applications

http://www.wikidata.org/entity/Q34062142

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Supportive or detrimental roles of P2Y receptors in brain pathology?--The two faces of P2Y receptors in stroke and neurodegeneration detected in neural cell and in animal model studies P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses Structure of the human P2Y12 receptor in complex with an antithrombotic drug Permeation of fluorophore-conjugated phalloidin into live hair cells of the inner ear is modulated by P2Y receptors.4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors Smoking enhances the proinflammatory effects of nucleotides on cytokine release from human lung.Pharmacochemistry of the platelet purinergic receptors.Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells.Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells.Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation Putative roles of purinergic signaling in human immunodeficiency virus-1 infection Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.Selective activation of KCa3.1 and CRAC channels by P2Y2 receptors promotes Ca(2+) signaling, store refilling and migration of rat microglial cells Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation.P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions Intercellular Ca(2+) waves: mechanisms and function.Nucleotides Acting at P2Y Receptors: Connecting Structure and Function.G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma Virtual screening leads to the discovery of novel non-nucleotide P2Y₁ receptor antagonists.Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation.Xenin-25 increases cytosolic free calcium levels and acetylcholine release from a subset of myenteric neurons.Molecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes.Purinergic receptor blockade in the retrotrapezoid nucleus attenuates the respiratory chemoreflexes in awake rats Do Cyclosporine A, an IL-1 Receptor Antagonist, Uridine Triphosphate, Rebamipide, and/or Bimatoprost Regulate Human Meibomian Gland Epithelial Cells?Hypersensitivity to ticagrelor and low response to clopidogrel: a case report.Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future.P2X receptors as drug targets.Independent purinergic mechanisms of central and peripheral chemoreception in the rostral ventrolateral medulla.P2 receptors and platelet function.Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues.Challenges to develop novel anti-inflammatory and analgesic drugs.Expression of mediators of purinergic signaling in human liver cell lines.Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold.Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand.Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors.The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.

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P2860

P2Y nucleotide receptors: promise of therapeutic applications

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2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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P2Y nucleotide receptors: promise of therapeutic applications

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P2Y nucleotide receptors: promise of therapeutic applications

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J.DRUDIS.2010.05.011

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Drug Discovery Today

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P2Y nucleotide receptors: promise of therapeutic applications

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Jean-Marie Boeynaems

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Kenneth A Jacobson

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P2860

Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts

Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis

Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis

Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family

Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes

A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models

Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

P2 receptors activated by uracil nucleotides--an update

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570-578

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scholarly article

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10.1016/J.DRUDIS.2010.05.011

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13-14

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15

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2010-06-02T00:00:00Z

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20594935

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2920619

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