Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.
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SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome.ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.Col2CreER(T2), a mouse model for a chondrocyte-specific and inducible gene deletion.Gene-gene interactions between TGF-β/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis.Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient ChondrocytesAttenuation of the progression of articular cartilage degeneration by inhibition of TGF-β1 signaling in a mouse model of osteoarthritisSMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.TGFβ signaling in cartilage development and maintenance.Epigenetic differences in human cartilage between mild and severe OA.Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling.Identification of genes required for the spontaneous repair of partial-thickness cartilage defects in immature rats.BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway.TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms.Epigenetic alterations and autoimmune disease.TGF β-1 administration during ex vivo expansion of human articular chondrocytes in a serum-free medium redirects the cell phenotype toward hypertrophy.Recent Insights into the Contribution of the Changing Hypertrophic Chondrocyte Phenotype in the Development and Progression of Osteoarthritis.
P2860
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P2860
Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@ast
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@en
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@nl
type
label
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@ast
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@en
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@nl
prefLabel
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@ast
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@en
Aberrant hypertrophy in Smad3- ...... mplication for osteoarthritis.
@nl
P2093
P2860
P356
P1476
Aberrant hypertrophy in Smad3- ...... implication for osteoarthritis
@en
P2093
Edward M Schwarz
Erik R Sampson
Jennifer H Jonason
Lisa M Flick
Regis J O'Keefe
Tian-Fang Li
Tzong-Jen Sheu
P2860
P304
P356
10.1002/ART.27537
P577
2010-08-01T00:00:00Z