Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
about
A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradationThe forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanismLigand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signalingPin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteinsJab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradationSmurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptorIdentification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTSIdentification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradationSmurf2 up-regulation activates telomere-dependent senescenceThe novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradationSmad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoNCHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcriptionLigand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteinsArkadia amplifies TGF-beta superfamily signalling through degradation of Smad7Critical regulation of TGFbeta signaling by Hsp90Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradationInduction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitroGene expression profiling reveals novel TGFbeta targets in adult lung fibroblastsKey role for ubiquitin protein modification in TGFβ signal transductionRegulation of TGF-β signal transduction by mono- and deubiquitylation of SmadsRegulation of TGF-β Superfamily Signaling by SMAD Mono-UbiquitinationActivation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradationTwo short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoNAn expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2Transcriptional induction of Smurf2 ubiquitin ligase by TGF-betaNegative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cellsIncomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypesUbiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradationThe FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse developmentComprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancerp130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.Smurf-mediated differential proteolysis generates dynamic BMP signaling in germline stem cells during Drosophila testis development.Pin1 promotes transforming growth factor-beta-induced migration and invasion.The tale of transforming growth factor-beta (TGFbeta) signaling: a soigné enigma.Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation
P2860
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P2860
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
description
2000 nî lūn-bûn
@nan
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@ast
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@en
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@en-gb
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@nl
type
label
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@ast
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@en
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@en-gb
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@nl
prefLabel
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@ast
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@en
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@en-gb
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@nl
P2093
P921
P356
P1476
Smurf2 is a ubiquitin E3 ligas ...... g growth factor-beta signaling
@en
P2093
P304
P356
10.1074/JBC.C000580200
P407
P577
2000-11-24T00:00:00Z