Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography - Test2 - elhamkhani - TriplyDB

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

http://www.wikidata.org/entity/Q34067336

about

Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies.N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure New positron emission tomography tracer [(11)C]carvedilol reveals P-glycoprotein modulation kinetics.Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography.Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport.Clinical relevance of P-glycoprotein in drug therapy.P-glycoprotein-based loperamide-cyclosporine drug interaction at the rat blood-brain barrier: prediction from in vitro studies and extrapolation to humans.Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study.New horizon of MDR1 (P-glycoprotein) study.Improving the prediction of the brain disposition for orally administered drugs using BDDCS.Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy.Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo (R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP.Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications.Drug interactions at the blood-brain barrier: fact or fantasy?Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior.Compartmental models for apical efflux by P-glycoprotein--part 1: evaluation of model complexity.Role of P-glycoprotein in the distribution of the HIV protease inhibitor atazanavir in the brain and male genital tract.P-glycoprotein related drug interactions: clinical importance and a consideration of disease states.Treatment of MDR1 mutant dogs with macrocyclic lactones Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain.Potential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging.Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions.Transporter effects on cell permeability in drug delivery.Efflux proteins at the blood-brain barrier: review and bioinformatics analysis.Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.Irradiation of rat brain reduces P-glycoprotein expression and function.Frequency of the nt230 (del4) MDR1 mutation in Collies and related dog breeds in Germany.Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil.Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier.A self-destructive nanosweeper that captures and clears amyloid β-peptides.

P2860

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P2860

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

http://www.wikidata.org/entity/Q34067336

description

1998 nî lūn-bûn

@nan

1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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1998 թվականի օգոստոսին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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Complete in vivo reversal of P ...... h positron emission tomography

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Fluks E

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Franssen EJ

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Hendrikse NH

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P2860

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

The blood-brain barrier. Transport across the cerebral endothelium.

99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein.

Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1.

The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance.

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blood–brain barrier

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1565536

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