Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo.
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Renal transport of uric acid: evolving concepts and uncertaintiesAre either or both hyperuricemia and xanthine oxidase directly toxic to the vasculature? A critical appraisalEvolutionary history and metabolic insights of ancient mammalian uricasesUric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerationsSite-specific bioconjugation of a murine dihydrofolate reductase enzyme by copper(I)-catalyzed azide-alkyne cycloaddition with retained activityUric Acid Nephrolithiasis: A Systemic Metabolic Disorder.Serum Uric Acid Relation for Hearing Threshold ShiftA Trivalent Enzymatic System for Uricolytic Therapy of HPRT Deficiency and Lesch-Nyhan Disease.Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipientsNLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts.Relationship between serum uric Acid and bone mineral density in the general population and in rats with experimental hyperuricemia.An update on the pathology and clinical management of gouty arthritis.A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development PropertiesThe renal phenotype of allopurinol-treated HPRT-deficient mouse.Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegenerationUric acid correlates to oxidation and inflammation in opposite directions in women.Critical appraisal of the role of pegloticase in the management of gout.Gout in 2010: progress and controversies in treatment.Allopurinol, uric acid, and oxidative stress in cardiorenal disease.Urate in Parkinson's disease: more than a biomarker?Evaluation and treatment of gout as a chronic disease.Molecular basis of oxidative stress in gouty arthropathy.Approaches towards molecular amplification for sensing.Targeting urate to reduce oxidative stress in Parkinson disease.No causal effect of serum urate on bone-related outcomes among a population of postmenopausal women and elderly men of Chinese Han ethnicity--a Mendelian randomization study.The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzymeGout and Risk of Fracture in Women: A Prospective Cohort Study.Pegloticase in gout treatment - safety issues, latest evidence and clinical considerations.Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid.Asymptomatic hyperuricemia: is it time to intervene?Heat stress impairs mitochondria functions and induces oxidative injury in broiler chickens.
P2860
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P2860
Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@ast
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@en
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@nl
type
label
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@ast
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@en
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@nl
prefLabel
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@ast
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@en
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@nl
P2093
P2860
P356
P1476
Treating gout with pegloticase ...... cid as an antioxidant in vivo.
@en
P2093
Denise Jaggers
Edna Scarlett
Ines Santisteban
John S Sundy
L Jackson Roberts
Michael S Hershfield
Nancy J Ganson
Susan J Kelly
P2860
P304
14351-14356
P356
10.1073/PNAS.1001072107
P407
P577
2010-07-26T00:00:00Z