Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. - Test2 - elhamkhani - TriplyDB

Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.

Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.

http://www.wikidata.org/entity/Q34088201

about

Fragile X syndrome and targeted treatment trials.Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes Fragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses PAK in Alzheimer disease, Huntington disease and X-linked mental retardation Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model.Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.Translational animal models of autism and neurodevelopmental disorders.Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice.Long-term memory deficits are associated with elevated synaptic ERK1/2 activation and reversed by mGluR5 antagonism in an animal model of autism.Fragile X syndrome: an update on developing treatment modalities.p75 regulates Purkinje cell firing by modulating SK channel activity through Rac1.The biochemistry of memory: The 26year journey of a 'new and specific hypothesis'.Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome.Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.Dendritic spine dysgenesis contributes to hyperreflexia after spinal cord injury.Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory.Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond.Targeted treatments for fragile X syndrome.Estrogen promotes learning-related plasticity by modifying the synaptic cytoskeleton.Abnormalities of the Duo/Ras-related C3 botulinum toxin substrate 1/p21-activated kinase 1 pathway drive myosin light chain phosphorylation in frontal cortex in schizophrenia.LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells.Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons.Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis.Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulb.Dendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker.FMRP regulates actin filament organization via the armadillo protein p0071.GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling.Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models.

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Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.

http://www.wikidata.org/entity/Q34088201

description

2010 nî lūn-bûn

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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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Physiological activation of sy ...... e model of fragile X syndrome.

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Physiological activation of sy ...... e model of fragile X syndrome.

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Physiological activation of synaptic Rac>PAK

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Physiological activation of sy ...... e model of fragile X syndrome.

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Physiological activation of sy ...... e model of fragile X syndrome.

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Physiological activation of synaptic Rac>PAK

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Physiological activation of sy ...... e model of fragile X syndrome.

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Physiological activation of sy ...... e model of fragile X syndrome.

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Physiological activation of synaptic Rac>PAK

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JNEUROSCI.1077-10.2010

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Journal of Neuroscience

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Physiological activation of sy ...... e model of fragile X syndrome.

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P2093

Alex H Babayan

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Christine M Gall

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Christopher S Rex

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Eniko A Kramár

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Gary Lynch

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Julie C Lauterborn

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Lulu Y Chen

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P2860

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor

The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus

Learning induces neurotrophin signaling at hippocampal synapses

Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease

Biology of the p21-activated kinases

Actin, a central player in cell shape and movement

Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome.

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10977-10984

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10.1523/JNEUROSCI.1077-10.2010

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33

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20720104

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2929244

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