A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia.
about
Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST]The effects of microRNA on the absorption, distribution, metabolism and excretion of drugsMicroRNA-433 inhibits cell proliferation in hepatocellular carcinoma by targeting p21 activated kinase (PAK4)The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesisDifferential allelic expression of c.1568C > A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3'UTR.HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience.Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice.Differentially expressed microRNAs in chondrocytes from distinct regions of developing human cartilage.A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells.Molecular basis of differential target regulation by miR-96 and miR-182: the Glypican-3 as a model.MiR-204 is responsible for inherited retinal dystrophy associated with ocular colobomamicroRNAs and inherited retinal dystrophies.Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical ImplicationsMicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA.Histone Deacetylases in Bone Development and Skeletal Disorders.Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer.MicroRNA variants as genetic determinants of bone massMicroRNA-433 inhibits liver cancer cell migration by repressing the protein expression and function of cAMP response element-binding protein.Lysine Acetylation and Deacetylation in Brain Development and NeuropathiesMiR-433-3p suppresses cell growth and enhances chemosensitivity by targeting CREB in human gliomaRegulation of microRNA expression and function by nuclear receptor signaling.Genetic variation in the epigenetic machinery and mental health.microRNAs and cartilage.Modulation of epigenetic regulators and cell fate decisions by miRNAs.Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes.Integrating massively parallel sequencing into diagnostic workflows and managing the annotation and clinical interpretation challenge.Histone deacetylase 6 in health and disease.Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases.A non-coding variant in the 5' UTR of DLG3 attenuates protein translation to cause non-syndromic intellectual disability.Histone Deacetylases in Cartilage Homeostasis and Osteoarthritis.A 3'-UTR mutation creates a microRNA target site in the GFPT1 gene of patients with congenital myasthenic syndrome.CFTR mRNA expression is regulated by an upstream open reading frame and RNA secondary structure in its 5' untranslated region.Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells.MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression.Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution.MiR-433 and miR-22 dysregulations induce HDAC6 overexpression and ciliary loss in cholangiocarcinoma.HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia.MicroRNAs in orthopaedic research: Disease associations, potential therapeutic applications, and perspectives.miR-433 inhibits breast cancer cell growth via the MAPK signaling pathway by targeting Rap1a.
P2860
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P2860
A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@ast
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@en
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@nl
type
label
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@ast
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@en
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@nl
prefLabel
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@ast
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@en
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@nl
P2093
P2860
P50
P356
P1476
A mutation in the 3'-UTR of th ...... ant X-linked chondrodysplasia.
@en
P2093
Benoit Arveiler
Benoit Laloo
Camille Blanchard
Delphine Simon
Ingrid Burgelin
Isabelle Coupry
Malika Barillot
Michèle Marche
Nicolas Chassaing
Thomas Barnetche
P2860
P304
P356
10.1093/HMG/DDQ083
P50
P577
2010-02-24T00:00:00Z