Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library.
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Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New BiocatalystsRecombinant Lipases and Phospholipases and Their Use as Biocatalysts for Industrial ApplicationsComputer aided enzyme design and catalytic conceptsThe Metagenome-Derived Enzymes LipS and LipT Increase the Diversity of Known LipasesReshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolutionValidating computer simulations of enantioselective catalysis; reproducing the large steric and entropic contributions in Candida Antarctica lipase BMany pathways in laboratory evolution can lead to improved enzymes: how to escape from local minima.An automated flow for directed evolution based on detection of promiscuous scaffolds using spatial and electrostatic properties of catalytic residues.Engineering yeast hexokinase 2 for improved tolerance toward xylose-induced inactivation.Directed evolution by using iterative saturation mutagenesis based on multiresidue sites.Improvement of biocatalysts for industrial and environmental purposes by saturation mutagenesisStructure-based design of combinatorial mutagenesis librariesCombinatorial library based engineering of Candida antarctica lipase A for enantioselective transacylation of sec-alcohols in organic solvent.Identification of novel esterase-active enzymes from hot environments by use of the host bacterium Thermus thermophilus.Kinetics of binding of fluorescent ligands to enzymes with engineered access tunnels.Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space.Technology prospecting on enzymes: application, marketing and engineering.New tools for exploring "old friends-microbial lipases".Increasing the activity and enantioselectivity of lipases by sol-gel immobilization: further advancements of practical interest.Lipase improvement: goals and strategies.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Chemoenzymatic dynamic kinetic resolution: a powerful tool for the preparation of enantiomerically pure alcohols and amines.Arylmalonate decarboxylase-a highly selective bacterial biocatalyst with unknown function.NADH-dependent biosensor in Saccharomyces cerevisiae: principle and validation at the single cell level.Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution.Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis.What are the Limitations of Enzymes in Synthetic Organic Chemistry?Removing the Active-Site Flap in Lipase A from Candida antarctica Produces a Functional Enzyme without Interfacial Activation.Yeast Kluyveromyces lactis as host for expression of the bacterial lipase: cloning and adaptation of the new lipase gene from Serratia sp.Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform.Homologous yeast lipases/acyltransferases exhibit remarkable cold-active propertiesThe short form of the recombinant CAL-A-type lipase UM03410 from the smut fungus Ustilago maydis exhibits an inherent trans-fatty acid selectivityAltering the scissile fatty acid binding site ofCandida antarcticalipase A by protein engineering for the selective hydrolysis of medium chain fatty acids
P2860
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P2860
Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library.
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2011 nî lūn-bûn
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2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Combinatorial reshaping of the ...... n extremely condensed library.
@ast
Combinatorial reshaping of the ...... n extremely condensed library.
@en
Combinatorial reshaping of the ...... n extremely condensed library.
@nl
type
label
Combinatorial reshaping of the ...... n extremely condensed library.
@ast
Combinatorial reshaping of the ...... n extremely condensed library.
@en
Combinatorial reshaping of the ...... n extremely condensed library.
@nl
prefLabel
Combinatorial reshaping of the ...... n extremely condensed library.
@ast
Combinatorial reshaping of the ...... n extremely condensed library.
@en
Combinatorial reshaping of the ...... n extremely condensed library.
@nl
P2093
P2860
P356
P1476
Combinatorial reshaping of the ...... n extremely condensed library.
@en
P2093
Anders G Sandström
Jan-E Bäckvall
Jonas Nyhlén
Karin Engström
Ylva Wikmark
P2860
P356
10.1073/PNAS.1111537108
P407
P577
2011-12-16T00:00:00Z