KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. - Test2 - elhamkhani - TriplyDB

KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.

KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.

http://www.wikidata.org/entity/Q34152331

about

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1 Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway Mechanism and regulation of incisions during DNA interstrand cross-link repair Diseases associated with defective responses to DNA damage Postreplicative mismatch repair.Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1.Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer.FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.Rescue of replication failure by Fanconi anaemia proteins.What is wrong with Fanconi anemia cells?Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs.Maintenance of genome stability by Fanconi anemia proteins.The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA.The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81.Toward precision medicine in glioblastoma: the promise and the challenges.What is the DNA repair defect underlying Fanconi anemia?Exo1 independent DNA mismatch repair involves multiple compensatory nucleases.Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease.Regulatory mechanisms of incomplete huntingtin mRNA splicing Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication

P2860

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P2860

KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.

http://www.wikidata.org/entity/Q34152331

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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type

label

KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

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PNAS.1011081107

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.

@en

P2093

Josef Jiricny

http://www.w3.org/2001/XMLSchema#string

Kana Nishihara

http://www.w3.org/2001/XMLSchema#string

Katja Kratz

http://www.w3.org/2001/XMLSchema#string

Kazunori Yoshikiyo

http://www.w3.org/2001/XMLSchema#string

Kouji Hirota

http://www.w3.org/2001/XMLSchema#string

Satoshi Horimoto

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2

Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair

How the fanconi anemia pathway guards the genome

Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins

Identification of novel restriction endonuclease-like fold families among hypothetical proteins.

The PD-(D/E)XK superfamily revisited: identification of new members among proteins involved in DNA metabolism and functional predictions for domains of (hitherto) unknown function.

FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2

DNA mismatch repair: functions and mechanisms

P304

21553-21557

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P31

scholarly article

P356

10.1073/PNAS.1011081107

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P407

P433

50

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P478

107

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P50

Hitoshi Kurumizaka

Shunichi Takeda

P577

2010-11-29T00:00:00Z

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P5875

49643525

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21115814

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3003052

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