KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.
about
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathwayDNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathwayMechanism and regulation of incisions during DNA interstrand cross-link repairDiseases associated with defective responses to DNA damagePostreplicative mismatch repair.Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1.Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayFAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer.FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitroInvolvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.Rescue of replication failure by Fanconi anaemia proteins.What is wrong with Fanconi anemia cells?Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemiaFan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs.Maintenance of genome stability by Fanconi anemia proteins.The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA.The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81.Toward precision medicine in glioblastoma: the promise and the challenges.What is the DNA repair defect underlying Fanconi anemia?Exo1 independent DNA mismatch repair involves multiple compensatory nucleases.Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responsesHistone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in miceMouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease.Regulatory mechanisms of incomplete huntingtin mRNA splicingUbiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication
P2860
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P2860
KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@ast
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@en
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@nl
type
label
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@ast
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@en
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@nl
prefLabel
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@ast
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@en
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@nl
P2093
P2860
P50
P356
P1476
KIAA1018/FAN1 nuclease protect ...... erstrand cross-linking agents.
@en
P2093
Josef Jiricny
Kana Nishihara
Katja Kratz
Kazunori Yoshikiyo
Kouji Hirota
Satoshi Horimoto
P2860
P304
21553-21557
P356
10.1073/PNAS.1011081107
P407
P577
2010-11-29T00:00:00Z