FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro
about
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase ηXPF knockout via CRISPR/Cas9 reveals that ERCC1 is retained in the cytoplasm without its heterodimer partner XPF.Involvement of translesion synthesis DNA polymerases in DNA interstrand crosslink repairA role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites.FANCD2 and DNA Damage.DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway.Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation.Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease.Preparation of Stable Nitrogen Mustard DNA Interstrand Cross-Link Analogs for Biochemical and Cell Biological Studies.A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslinkUbiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication
P2860
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P2860
FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro
description
2015 nî lūn-bûn
@nan
2015 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@ast
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@en
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@nl
type
label
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@ast
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@en
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@nl
prefLabel
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@ast
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@en
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@nl
P2093
P2860
P356
P1476
FANCD2-associated nuclease 1, ...... terstrand cross-links in vitro
@en
P2093
Josef Jiricny
Julia Pizzolato
Orlando D Schärer
Shivam Mukherjee
P2860
P304
22602-22611
P356
10.1074/JBC.M115.663666
P407
P577
2015-07-28T00:00:00Z