Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? - Test2 - elhamkhani - TriplyDB

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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5'-UTR RNA G-quadruplexes: translation regulation and targeting Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family G-quadruplexes and their regulatory roles in biology Effects of messenger RNA structure and other translational control mechanisms on major histocompatibility complex-I mediated antigen presentation A minimal i-motif stabilized by minor groove G:T:G:T tetrads RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5′ End-Stacked Dimeric Parallel G-Quadruplexes Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes Monomer-dimer equilibrium for the 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural study Carbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-end Structural basis of DNA quadruplex-duplex junction formation Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3)Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome Do we know whether potential G-quadruplexes actually form in long functional RNA molecules?The G4 genome G-Quadruplex in the NRF2 mRNA 5' Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines Targeting human telomeric G-quadruplex DNA and inhibition of telomerase activity with [(dmb)2Ru(obip)Ru(dmb)2](4+)Finding and characterizing the complexes of drug like molecules with quadruplex DNA: combined use of an enhanced hydroxyl radical cleavage protocol and NMR Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second messengers Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses A Nitroxide-Tagged Platinum(II) Complex Enables the Identification of a DNA G-Quadruplex Binding Mode Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD.Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences.Selective Luminescent Labeling of DNA and RNA Quadruplexes by π-Extended Ruthenium Light-Up Probes.G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD.Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.Mapping the affinity landscape of Thrombin-binding aptamers on 2΄F-ANA/DNA chimeric G-Quadruplex microarrays Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide.Ball with hair: modular functionalization of highly stable G-quadruplex DNA nano-scaffolds through N2-guanine modification.Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

http://www.wikidata.org/entity/Q34174883

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Nature Reviews Drug Discovery

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Laurence H Hurley

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Shankar Balasubramanian

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Stephen Neidle

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Crystal structure of parallel quadruplexes from human telomeric DNA

The Hallmarks of Cancer

Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis

Highly prevalent putative quadruplex sequence motifs in human DNA

Prevalence of quadruplexes in the human genome.

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation

Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

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261-275

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10.1038/NRD3428

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4

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10

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2011-04-01T00:00:00Z

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50940411

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1049954039

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21455236

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3119469

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