Stability and the evolvability of function in a model protein
about
Rational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine DetoxificationComparing folding codes in simple heteropolymer models of protein evolutionary landscape: robustness of the superfunnel paradigm.Computationally mapping sequence space to understand evolutionary protein engineering.Evolution of sparsity and modularity in a model of protein allostery.Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence.Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach.Evolutionary dynamics on protein bi-stability landscapes can potentially resolve adaptive conflicts.Deletional protein engineering based on stable fold.Neutral evolution of protein-protein interactions: a computational study using simple models.Universal distribution of protein evolution rates as a consequence of protein folding physicsEvolving thermostability in mutant libraries of ligninolytic oxidoreductases expressed in yeast.Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Hyperthermophilic phosphotriesterases/lactonases for the environment and human health.Computational Cellular Dynamics Based on the Chemical Master Equation: A Challenge for Understanding Complexity.Directed evolution to re-adapt a co-evolved network within an enzyme.Biophysics of protein evolution and evolutionary protein biophysicsBringing molecules back into molecular evolution.SELECTIVE ADVANTAGE OF RECOMBINATION IN EVOLVING PROTEIN POPULATIONS: A LATTICE MODEL STUDY.Variations within class-A β-lactamase physiochemical properties reflect evolutionary and environmental patterns, but not antibiotic specificityComparative laboratory evolution of ordered and disordered enzymes.Bacterial persistence increases as environmental fitness decreases.A Gradient of Sitewise Diversity Promotes Evolutionary Fitness for Binder Discovery in a Three-Helix Bundle Protein Scaffold.Redesigning symmetry-related "mini-core" regions of FGF-1 to increase primary structure symmetry: thermodynamic and functional consequences of structural symmetry.Fast, cheap and out of control--Insights into thermodynamic and informatic constraints on natural protein sequences from de novo protein design.Functionality and the evolution of marginal stability in proteins: inferences from lattice simulationsProteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins.Long-term evolution is surprisingly predictable in lattice proteinsStructural evolution of proteinlike heteropolymers.Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints.Statistical geometry of lattice chain polymers with voids of defined shapes: sampling with strong constraints.Negative Epistasis in Experimental RNA Fitness Landscapes.Molecular ensembles make evolution unpredictable.Evolution of off-lattice model proteins under ligand binding constraints.The response to selection in Glycoside Hydrolase Family 13 structures: A comparative quantitative genetics approach.Binding constraints on the evolution of enzymes and signalling proteins: the important role of negative pleiotropy.Environmental change exposes beneficial epistatic interactions in a catalytic RNA.Neutral evolution of proteins: The superfunnel in sequence space and its relation to mutational robustnessSynchronous birth is a dominant pattern in receptor-ligand evolution
P2860
Q27684298-7294445E-3278-4BDE-B098-C8F76C0832B1Q30344005-095860EC-60F0-4373-A439-58C0E9740BD3Q30365927-6CA2083C-12B9-4181-A52C-AB60D21665BFQ30374677-600E6FEE-2D91-498C-BC8B-DF36BCE54538Q30399998-AB686E1F-E113-4176-A5CB-29DF164B88B7Q30401074-0973A75B-DE4D-46E9-8DC8-9A88C90C8E7AQ30421817-09E7907A-3468-4DA2-8662-F75D58E6A8F5Q30424765-999AFA37-824D-49AD-8461-9A21C5EDA06CQ33306166-A1650434-BA9D-4167-99F1-8E6641E6ED20Q33529576-CAB020F8-FB2F-4CDF-94C2-FB506EDF8B26Q33542837-A97154C6-563B-4BA8-91B4-2048E80A5778Q33590790-BBE1DA30-7918-4CEA-9B45-DD64C046A2C0Q33662327-FB7946DF-B19F-4217-8907-EE25E74C63EBQ33836147-122C04E8-9B52-4A34-B600-D789471D248BQ34095513-1325EDDB-853B-49E6-8311-2E7F8A29F811Q34311852-1CA29301-B214-45C8-A1C6-5DD618251F77Q34325465-0498C1F1-2667-4B31-B889-10430F53FBEBQ34600039-4834925E-76BC-460C-ACD3-4AA06E927D44Q34845380-D6DA04D0-C9BE-4310-979E-CEAC92D6069BQ35351471-D0DB0BB4-C7AF-450D-940E-B2F009FA4331Q35881863-3CB9FDBF-3598-49CB-BE10-A562B014BC82Q36293727-C9E64C99-3569-4674-BE34-929342D3B484Q36477003-8ED347C7-37E0-4253-92A3-5E5FD2239695Q36868063-2E8F7DF0-F719-4D6F-850A-F9870E4CA475Q37173128-5E8708FC-A4F3-4AD2-AD78-866B3FB3FB17Q39183554-DAEEC293-4997-4162-B38C-C4BD3FD43A7BQ39863264-FEA10D52-8A64-442B-9B20-47887B9E5CA1Q41536976-9FBBD950-ABF5-4B8D-AFFD-27F3DDCC8904Q41768727-1D966473-EF56-4420-A614-F371B21F5ED7Q41828093-1DEB5E07-9B85-4B7A-8699-A905F041B792Q46812108-0FBD2432-BEF4-4670-9AC8-33B558C4707DQ47112377-7FD10CF4-1FA7-46CE-A350-9E5523A829D2Q51508458-2054E405-71D9-4619-88E1-F46C15ADE9DDQ55284021-F5E35774-D69D-4BF1-98B6-9B7FFDC09B39Q55400430-3F873EB9-FB8B-475F-AF9F-7EA5A64162FCQ55436455-4872E987-7728-4193-9AB4-1EA0B52FC886Q57077672-527E0CD5-2697-4EE5-9B97-8E6EC79402B8Q58782644-5F923399-5254-4FA9-8026-B88A5A833E2B
P2860
Stability and the evolvability of function in a model protein
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Stability and the evolvability of function in a model protein
@ast
Stability and the evolvability of function in a model protein
@en
Stability and the evolvability of function in a model protein
@nl
type
label
Stability and the evolvability of function in a model protein
@ast
Stability and the evolvability of function in a model protein
@en
Stability and the evolvability of function in a model protein
@nl
prefLabel
Stability and the evolvability of function in a model protein
@ast
Stability and the evolvability of function in a model protein
@en
Stability and the evolvability of function in a model protein
@nl
P2860
P50
P1433
P1476
Stability and the evolvability of function in a model protein
@en
P2860
P304
P356
10.1016/S0006-3495(04)74329-5
P407
P577
2004-05-01T00:00:00Z
P698
P818
q-bio/0401038