about
Stability-mediated epistasis constrains the evolution of an influenza proteinStructure-guided recombination creates an artificial family of cytochromes P450.Evolution favors protein mutational robustness in sufficiently large populationsIn the light of directed evolution: pathways of adaptive protein evolutionProtein stability promotes evolvabilityThermodynamic prediction of protein neutralityProbing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prionsApparent dependence of protein evolutionary rate on number of interactions is linked to biases in protein-protein interactions data setsEvolutionary rate depends on number of protein-protein interactions independently of gene expression level: responseThe interface of protein structure, protein biophysics, and molecular evolutionThermodynamics of neutral protein evolutionImproving pandemic influenza risk assessment.Estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant A(H1N1)pdm09 influenza virusesStructural determinants of the rate of protein evolution in yeast.Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice.A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase.The global spread of drug-resistant influenza.Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.Software for the analysis and visualization of deep mutational scanning data.A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.Inferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin.Consensus protein design without phylogenetic biasEpistatically interacting substitutions are enriched during adaptive protein evolutionBroad protection against influenza infection by vectored immunoprophylaxis in mice.Parallel evolution of influenza across multiple spatiotemporal scales.An experimentally determined evolutionary model dramatically improves phylogenetic fit.The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin.Why highly expressed proteins evolve slowly.Permissive secondary mutations enable the evolution of influenza oseltamivir resistance.Stability and the evolvability of function in a model proteinAn experimentally informed evolutionary model improves phylogenetic fit to divergent lactamase homologsPredicting the tolerance of proteins to random amino acid substitution.Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.Evolving strategies for enzyme engineering.Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV's Envelope Protein on Viral Replication in Cell CultureSite-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs.Positive Selection in CD8+ T-Cell Epitopes of Influenza Virus Nucleoprotein Revealed by a Comparative Analysis of Human and Swine Viral Lineages.Complete mapping of viral escape from neutralizing antibodiesDeep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxAThe elongation of yeast prion fibers involves separable steps of association and conversion.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
ricercatore
@it
հետազոտող
@hy
name
Jesse Bloom
@fr
Jesse D Bloom
@en
Jesse D Bloom
@es
Jesse D Bloom
@nl
Jesse D Bloom
@sl
type
label
Jesse Bloom
@fr
Jesse D Bloom
@en
Jesse D Bloom
@es
Jesse D Bloom
@nl
Jesse D Bloom
@sl
prefLabel
Jesse Bloom
@fr
Jesse D Bloom
@en
Jesse D Bloom
@es
Jesse D Bloom
@nl
Jesse D Bloom
@sl
P244
P1053
C-6837-2013
P106
P21
P214
37147905026379090632
P244
no2016132377
P31
P3829
P496
0000-0003-1267-3408
P734
P735
P7859
lccn-no2016132377