Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.
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mTOR is a key modulator of ageing and age-related diseaseThe MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegansThe circadian clock coordinates ribosome biogenesisIntegration of the unfolded protein and oxidative stress responses through SKN-1/NrfInduction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathwaysMechanisms of aging-related proteinopathies in Caenorhabditis elegansTOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxOHaploinsufficiency of akt1 prolongs the lifespan of miceMutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegansThe m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size controlC. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan ExtensionA genome-wide screen of bacterial mutants that enhance dauer formation in C. elegansDetecting translational regulation by change point analysis of ribosome profiling data setsThe SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard dietLIN-35/Rb causes starvation-induced germ cell apoptosis via CED-9/Bcl2 downregulation in Caenorhabditis elegans.A cytoprotective perspective on longevity regulationAltered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteomeThe general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegansAMPK at the nexus of energetics and aging.Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms.The Mediator complex of Caenorhabditis elegans: insights into the developmental and physiological roles of a conserved transcriptional coregulator.Translational regulation in nutrigenomics.Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling.Function and Regulation of Lipid Biology in Caenorhabditis elegans Aging.Proteomic Analysis of eIF5B Silencing-Modulated Proteostasis.Systems biology in aging: linking the old and the young.GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.Pharmacological lifespan extension of invertebratesω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.Role of oxygen consumption in hypoxia protection by translation factor depletion.eIF4B stimulates translation of long mRNAs with structured 5' UTRs and low closed-loop potential but weak dependence on eIF4G.Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans.Interrelation between protein synthesis, proteostasis and life spanRole of translation initiation factor 4G in lifespan regulation and age-related healthDirect and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators.The search for evolutionary developmental origins of aging in zebrafish: a novel intersection of developmental and senescence biology in the zebrafish model system.Genome-scale studies of aging: challenges and opportunities
P2860
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P2860
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Life span extension via eIF4G ...... gene expression in C. elegans.
@ast
Life span extension via eIF4G ...... gene expression in C. elegans.
@en
Life span extension via eIF4G ...... gene expression in C. elegans.
@nl
type
label
Life span extension via eIF4G ...... gene expression in C. elegans.
@ast
Life span extension via eIF4G ...... gene expression in C. elegans.
@en
Life span extension via eIF4G ...... gene expression in C. elegans.
@nl
prefLabel
Life span extension via eIF4G ...... gene expression in C. elegans.
@ast
Life span extension via eIF4G ...... gene expression in C. elegans.
@en
Life span extension via eIF4G ...... gene expression in C. elegans.
@nl
P2093
P2860
P1433
P1476
Life span extension via eIF4G ...... gene expression in C. elegans.
@en
P2093
Alan Hubbard
Aric N Rogers
Bradford W Gibson
Gordon J Lithgow
Gregg Czerwieniec
Krysta Felkey
Pankaj Kapahi
Simon Melov
P2860
P356
10.1016/J.CMET.2011.05.010
P577
2011-07-01T00:00:00Z