EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. - Test2 - elhamkhani - TriplyDB

EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.

EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.

http://www.wikidata.org/entity/Q34206278

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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo.Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.Animal models of soft-tissue sarcoma.Molecular pathways: targeting ETS gene fusions in cancer.EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance.Mesenchymal stem cell transformation and sarcoma genesis.Primary neoplasms of bones in mice: retrospective study and review of literature Promiscuous partnerships in Ewing's sarcoma.The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS.A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis The first European interdisciplinary ewing sarcoma research summit Mouse models of sarcomas: critical tools in our understanding of the pathobiology Recent advances in the molecular pathogenesis of Ewing's sarcoma.The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute.Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish.ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma.RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein.Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer.Efficacy of ATR inhibitors as single agents in Ewing sarcoma.Modeling sarcomagenesis using multipotent mesenchymal stem cells.The adolescent and young adult with cancer: state of the art -- bone tumors.Xenograft and genetically engineered mouse model systems of osteosarcoma and Ewing's sarcoma: tumor models for cancer drug discovery.Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine.An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation.Downstream EWS/FLI1 - upstream Ewing's sarcoma The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation.TEThered to Runx: novel binding partners for runx factors.EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma.Targeting the p53 Pathway in Ewing Sarcoma.Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family.Ewing's Sarcoma: Development of RNA Interference-Based Therapy for Advanced Disease.Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma.Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.

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EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.

http://www.wikidata.org/entity/Q34206278

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2008 nî lūn-bûn

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Cancer Research

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EWS-FLI1 induces developmental ...... n in a transgenic mouse model.

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Fenghua Jin

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Guillermina Lozano

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John M Parant

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Manoj K Pandey

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Michael Deavers

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Patrick P Lin

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Shunbin Xiong

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P2860

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.

EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report.

Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells.

Endothelial cell-cell junctions: happy together.

Experimental evidence for a neural origin of Ewing's sarcoma of bone.

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

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8968-8975

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21

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68

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18974141

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