Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. - Test2 - elhamkhani - TriplyDB

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

http://www.wikidata.org/entity/Q34214639

about

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress Emerging roles of Nrf2 signal in non-small cell lung cancer TrxR1 as a potent regulator of the Nrf2-Keap1 response system Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells.NRF2 and cancer: the good, the bad and the importance of context.Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway.Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.Renal efflux transporter expression in pregnant mice with Type I diabetes Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin.Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor.Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease Nrf2: a potential target for new therapeutics in liver disease.Targeting nrf2-mediated gene transcription by triterpenoids and their derivatives.Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice.Aging increases the susceptibility of cisplatin-induced nephrotoxicity Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.Protective effect of metalloporphyrins against cisplatin-induced kidney injury in mice.The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice.Comparative nephrotoxicity of Cisplatin and nedaplatin: mechanisms and histopathological characteristics.An overview of transcriptional regulation in response to toxicological insult.The Nrf2 pathway in the progression of renal disease.Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity.Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.CDDO and Its Role in Chronic Diseases.Promoter region variation in NFE2L2 influences susceptibility to ototoxicity in patients exposed to high cumulative doses of cisplatin.Keap1 hypomorphism protects against ischemic and obstructive kidney disease Nrf2 activators as potential modulators of injury in human kidney cells.Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against Podocytopathy.

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P2860

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

http://www.wikidata.org/entity/Q34214639

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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Transcriptional regulation of ...... platin-induced nephrotoxicity.

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Transcriptional regulation of ...... platin-induced nephrotoxicity.

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Cheryl E Rockwell

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Curtis D Klaassen

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Jose E Manautou

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Juergen Thomale

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Michael J Goedken

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P2860

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers

Identification of platform-independent gene expression markers of cisplatin nephrotoxicity.

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology

Transcriptomic analysis of nephrotoxicity induced by cephaloridine, a representative cephalosporin antibiotic

Multidrug resistance associated protein 2 mediates transport of prostaglandin E2

Transcription factor-kappa B (NF-kappa B) and renal disease.

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Lauren M Aleksunes

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2010-07-06T00:00:00Z

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45096889

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20605904

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2957774

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