Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.
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Restriction beyond the restriction point: mitogen requirement for G2 passagePhosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damagep38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosisProapoptotic function of the retinoblastoma tumor suppressor proteinA dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapyConnective tissue growth factor is required for normal follicle development and ovulationPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycleAltered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).Bcl11b is required for differentiation and survival of alphabeta T lymphocytesHot spots for allosteric regulation on protein surfacesConditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure.The retinoblastoma tumor-suppressor gene, the exception that proves the ruleRegulation of cellular genes in a chromosomal context by the retinoblastoma tumor suppressor proteinId2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors.Induction of programmed cell death by parvovirus H-1 in U937 cells: connection with the tumor necrosis factor alpha signalling pathway.Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakageLack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53.Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells.αB-crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation.The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction.Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell lineIdentification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancersTailoring to RB: tumour suppressor status and therapeutic response.PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression.Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells.ARF differentially modulates apoptosis induced by E2F1 and Myc.The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system.Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosisConditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system.The retinoblastoma protein regulates pericentric heterochromatin.Regulation of mouse thymidylate synthase gene expression in growth-stimulated cells: upstream S phase control elements are indistinguishable from the essential promoter elements.Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiationHuman mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.The evolving role of radiation therapy in the management of malignant melanomaTransgenic and knockout mice models to reveal the functions of tumor suppressor genes.Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents.Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen.Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.
P2860
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P2860
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@ast
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@en
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@nl
type
label
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@ast
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@en
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@nl
prefLabel
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@ast
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@en
Deficiency of retinoblastoma p ...... sponsive genes, and apoptosis.
@nl
P2093
P2860
P356
P1476
Deficiency of retinoblastoma p ...... esponsive genes, and apoptosis
@en
P2093
J R Bertino
P2860
P304
P356
10.1073/PNAS.92.12.5436
P407
P50
P577
1995-06-01T00:00:00Z