The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle - Test2 - elhamkhani - TriplyDB

The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle

The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle

http://www.wikidata.org/entity/Q28260808

about

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death UHRF1 plays a role in maintaining DNA methylation in mammalian cells Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer Conserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1 Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas Three SRA-domain methylcytosine-binding proteins cooperate to maintain global CpG methylation and epigenetic silencing in Arabidopsis.Downstream targets of homeobox gene HLX show altered expression in human idiopathic fetal growth restriction.Prediction of a gene regulatory network linked to prostate cancer from gene expression, microRNA and clinical data.Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases.Upregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1.A high-dimensional, deep-sequencing study of lung adenocarcinoma in female never-smokers The role of placental homeobox genes in human fetal growth restriction.Evidence that human blastomere cleavage is under unique cell cycle control.Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization.Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1 UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.Np95 is implicated in pericentromeric heterochromatin replication and in major satellite silencing UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.Digging deep into "dirty" drugs - modulation of the methylation machinery.Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition.Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells.UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.Paf15 expression correlates with rectal cancer prognosis, cell proliferation and radiation response.Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes.UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance.The Roles of the Methyl-CpG Binding Proteins in Cancer.The role of methyl-binding proteins in chromatin organization and epigenome maintenance.Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma.Up-regulation of UHRF1 by oncogenic Ras promoted the growth, migration, and metastasis of pancreatic cancer cells.The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.

P2860

Q24297549-FF09BE64-90F4-45CC-A1DD-B54FDCC879ED Q24297944-0C5F0FCF-8101-425D-B27B-156C5678CDDF Q24298944-57345B27-FCB7-4319-816F-0F557A5C6760 Q24311673-1E72DDE3-755A-4A25-8982-E2B9A9A3430A Q24318106-80388FD9-FF17-4CC4-B75B-E44FC7ED1DE6 Q24336152-CC594EE6-AF85-4E65-8D0B-932CE8B16107 Q27675158-0ECB6721-881C-4CD1-8FAA-E06D375A875B Q27675643-0671C18C-58CC-4346-866E-92BAB5571683 Q28073257-027EBDF8-1541-4D5C-8AFC-120E7B43FBC5 Q28082738-1B449815-5641-48C2-A12C-ADB8F085910D Q30491720-8C101C83-1BCD-432E-8AF7-CDA8ACF68751 Q33360264-6C9B3AB9-A5FF-46D3-B5DF-2CF86FD7E439 Q33556337-23BAB3D2-F339-4FF9-9EDB-A0B0495BC558 Q33686676-2F54A307-9CC0-47DE-ADEB-E8FF17AC8B80 Q34193178-A1AF7474-38A6-49C3-9415-D9B275BEAAE3 Q34277667-9F23A944-FCBD-4685-BA6A-AF38FA4DA8B5 Q34278046-9A9D51F0-FAC4-4BD1-AE48-C9AB30C2B12E Q34584344-14BDCDBB-DBC5-4ACF-8B4A-D562B97326AB Q34919909-14A450A4-8A41-400B-82A6-9288D7D56AC0 Q34962964-F05213CB-B798-40B2-B7DA-D63ED2CBEB14 Q34989248-C6EC186A-4E7F-4AD7-870B-7620400C2A10 Q35615994-05080DD6-E4D2-4145-AAD4-8C5CEFD2E360 Q35616432-086D1BDF-3CE4-45B6-AC3E-7117F8BFBB9E Q35642903-463BADD2-9BC7-47EA-9E5C-C789C83C0EA3 Q35650852-12617968-AEE4-442A-B998-3A18D2813814 Q36211327-A8167202-8354-4E6D-80F6-1D110246C753 Q36523796-B3E41F02-767B-4C38-B4A3-D2BD3F2C7F52 Q36768848-A9B2D4B6-2F7C-43C8-81EB-8D229CEA1CBA Q37152073-FBF22F55-BC8E-4F25-8F4D-D6921789B5C2 Q37269716-BFFBF4C2-28B7-4F0A-AE28-284D7C5DE660 Q37437654-25D3DF5B-FDE1-4430-B27B-793F23353847 Q37589996-BFBFD618-B9DC-4E13-A2F3-44F77B61875D Q37885195-FAF341E7-8AD4-47D1-B798-BCACCF110920 Q37937460-450BB39F-AF4D-404C-8DB1-E2A9F90F0514 Q37970067-74FDA8EA-5F95-4F9F-A4B5-DD60400B929D Q38313414-989AA8E5-34BC-4F6B-A8B4-573CC0D9CEFE Q38938491-142F6782-8831-44FA-9B89-9CABC4515850 Q39129140-471E13E6-3798-45E6-9540-2A77204CC7B5 Q39230518-715AFB2C-5178-449C-B4B4-FF27363E1970 Q39304639-14D79C24-677D-46A0-981C-1E686EE20638

P2860

The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle

http://www.wikidata.org/entity/Q28260808

description

2005 nî lūn-bûn

@nan

2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

The retinoblastoma gene and it ...... ansition during the cell cycle

@ast

The retinoblastoma gene and it ...... ansition during the cell cycle

@en

The retinoblastoma gene and it ...... ansition during the cell cycle

@nl

type

label

The retinoblastoma gene and it ...... ansition during the cell cycle

@ast

The retinoblastoma gene and it ...... ansition during the cell cycle

@en

The retinoblastoma gene and it ...... ansition during the cell cycle

@nl

prefLabel

The retinoblastoma gene and it ...... ansition during the cell cycle

@ast

The retinoblastoma gene and it ...... ansition during the cell cycle

@en

The retinoblastoma gene and it ...... ansition during the cell cycle

@nl

P1433

Q28260808-73A910D5-FDCC-43B9-9A4B-B52383CC43E3

P1476

Q28260808-6BF30AE5-6E3D-4132-B318-B1DFACBCDB5E

P2093

Q28260808-06005179-F581-4306-80F8-FBAE207AAF73

Q28260808-1869B0E3-7739-42F3-9E93-E1D76FAE11D1

Q28260808-73B3AB4A-98DA-4E6E-BFC9-A2F200D65DBB

Q28260808-778ED1F8-2257-4405-BF15-AD76D701063D

Q28260808-7DB765A9-9D77-4780-A6E0-1E20274E44D8

Q28260808-80F1AD2F-F7F7-4FA6-AD6A-00916FC0C67B

Q28260808-9C8B6F63-C906-47D2-BAEB-1A51D76CFD72

Q28260808-CB1E8484-98C2-4446-A402-DDA40A28BB21

P2860

Q28260808-0238F000-6D7C-4C46-8E26-65897DA66134

Q28260808-040E50E4-DB2D-48FE-86FC-BF07E3F0A4EC

Q28260808-04ACC4CE-43D9-4F8E-8486-642E519A14B5

Q28260808-05C7B3B3-C33B-4F07-AA37-51E197EC04FB

Q28260808-0CC9BA3E-4E4A-4365-802F-27E15B53D338

Q28260808-0FD801BC-5516-446B-A47B-11D4F53775A7

Q28260808-15657F6E-EAEA-4FEE-AD3A-0CF2C88369B2

Q28260808-1A49C315-436B-4283-9ABB-01D73502E90A

Q28260808-24E9BCFB-987D-4966-ADDB-75BA92D4DAB3

Q28260808-3543E063-4703-4550-81EA-51BB5D594A7B

P2888

Q28260808-E8024C39-BBD6-423B-AB19-0351E573D60F

P304

Q28260808-303D2C5B-78CF-4C1E-B7C1-0E22575A0360

P31

Q28260808-AF17FC35-FE84-428E-9D48-3C625FEC5415

P3181

Q28260808-FDC2ED7A-63D1-4DBF-A238-E51BE1D0833F

P356

Q28260808-37D1CA0E-7B4D-49E4-BF20-A6ED108C1BE1

P407

Q28260808-E1896A12-FF4C-4D05-9F27-B99FA927C915

P433

Q28260808-9AC672D2-6DE6-4FB8-BB7F-237C411F9C68

P478

Q28260808-5EBFC43C-7979-4946-9E0C-0C2376EF99E5

P50

Q28260808-8E5E4EB8-AD8B-43FC-8960-D536FE185764

Q28260808-E14C7390-9C28-4863-BA49-29626F35EAAE

P577

Q28260808-0BD81CA8-2ADD-470C-A38B-F7AE9D15F2AD

P6179

Q28260808-1D991A45-3448-47D0-87D7-881843578A2C

P698

Q28260808-79E7A6AF-6AED-4712-8ECA-D1525365D6C8

P921

Q28260808-D5E474D8-4DCF-49E8-9623-CC45FFEE9E8D

P3181

P356

P1433

P1476

The retinoblastoma gene and it ...... ansition during the cell cycle

@en

P2093

Christian D Muller

http://www.w3.org/2001/XMLSchema#string

Eric Mathieu

http://www.w3.org/2001/XMLSchema#string

Jean-Claude Siffert

http://www.w3.org/2001/XMLSchema#string

Kawtar Bathami

http://www.w3.org/2001/XMLSchema#string

Marc Mousli

http://www.w3.org/2001/XMLSchema#string

Michaël Jeanblanc

http://www.w3.org/2001/XMLSchema#string

Nadine Martinet

http://www.w3.org/2001/XMLSchema#string

Raphaël Hopfner

http://www.w3.org/2001/XMLSchema#string

P2860

ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain

The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity

Np95 is a histone-binding protein endowed with ubiquitin ligase activity

ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.

pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer

Aberrant expression of G(1)/S regulators is a frequent event in sporadic pituitary adenomas

Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding

Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition

Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression

P2888

P304

7337-7345

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2484545

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/SJ.ONC.1208878

http://www.w3.org/2001/XMLSchema#string

P407

P433

49

http://www.w3.org/2001/XMLSchema#string

P478

24

http://www.w3.org/2001/XMLSchema#string

P50

Christian Bronner

Abdul Qader Abbady

P577

2005-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P6179

1015660363

http://www.w3.org/2001/XMLSchema#string

P698

16007129

http://www.w3.org/2001/XMLSchema#string

P921