SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. - Test2 - elhamkhani - TriplyDB

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.

http://www.wikidata.org/entity/Q34289997

about

Epigenetics and aging Restricting retrotransposons: a review Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition Epigenetic perturbations in aging stem cells Roles for retrotransposon insertions in human disease Intracellular Mono-ADP-Ribosylation in Signaling and Disease Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory Preferential retrotransposition in aging yeast mother cells is correlated with increased genome instability.Retrotransposons shape species-specific embryonic stem cell gene expression Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds piRNA involvement in genome stability and human cancer Nuclear DNA damage signalling to mitochondria in ageing LINE-1 activity as molecular basis for genomic instability associated with light exposure at night Human Genomics. Sleeping dogs of the genome Regulatory activities of transposable elements: from conflicts to benefits.JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.Phosphorylation of ORF1p is required for L1 retrotransposition.The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp Population and clinical genetics of human transposable elements in the (post) genomic era.SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men.Sirtuin regulation in aging and injury Epigenetic regulation of ageing: linking environmental inputs to genomic stability.SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.DNA double strand break repair, aging and the chromatin connection.How retrotransposons shape genome regulation.Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein.Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila.What might retrotransposons teach us about aging?Effect of aging on stem cells.Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders Neuronal epigenetics and the aging synapse.SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.The effect of transposable elements on phenotypic variation: insights from plants to humans.SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence.Putative tumor suppression function of SIRT6 in endometrial cancer.The Chromatin Landscape of Cellular Senescence.SIRT6: Novel Mechanisms and Links to Aging and Disease.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.

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P2860

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.

http://www.wikidata.org/entity/Q34289997

description

2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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SIRT6 represses LINE1 retrotra ...... ion fails with stress and age.

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Nature Communications

P1476

SIRT6 represses LINE1 retrotra ...... sion fails with stress and age

@en

P2093

Andrei Seluanov

http://www.w3.org/2001/XMLSchema#string

Mehr Kashyap

http://www.w3.org/2001/XMLSchema#string

Michael Van Meter

http://www.w3.org/2001/XMLSchema#string

Sarallah Rezazadeh

http://www.w3.org/2001/XMLSchema#string

Timothy D Morello

http://www.w3.org/2001/XMLSchema#string

P2860

Initial sequencing and analysis of the human genome

Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs

Hot L1s account for the bulk of retrotransposition in the human population

DNA Damage, Aging, and Cancer

Initial sequencing and comparative analysis of the mouse genome

Human SIRT6 promotes DNA end resection through CtIP deacetylation

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

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10.1038/NCOMMS6011

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5

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Anthony J. Geneva

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2014-09-23T00:00:00Z

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266026738

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1042110415

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25247314

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retrotransposon

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4185372

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