Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.
about
Chemical Proteomic Profiling of Human MethyltransferasesSimultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.Chemo- and site-selective derivatizations of natural products enabling biological studies.Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells.Streamlining chemical probe discovery: libraries of "fully functionalized" small molecules for phenotypic screening.Target deconvolution techniques in modern phenotypic profiling.Selective fluorescence detection of small-molecule-binding proteins by using a dual photoaffinity labeling system.Target identification for small bioactive molecules: finding the needle in the haystack.Target identification and mechanism of action in chemical biology and drug discovery.Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach.Discovery of a Potent Anti-tumor Agent through Regioselective Mono-N-acylation of 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine.Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores.Ligand and Target Discovery by Fragment-Based Screening in Human Cells.Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300.From noncovalent to covalent bonds: a paradigm shift in target protein identification.Sum of the parts: mass spectrometry-based metabolomicsRecent advances in target characterization and identification by photoaffinity probes.TAK1 selective inhibition: state of the art and future opportunities.Affinity purification in target identification: the specificity challenge.Chalcone: A Privileged Structure in Medicinal Chemistry.Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase.Target Identification of Kinase Inhibitor Alisertib (MLN8237) by Using DNA-Programmed Affinity Labeling.Photoaffinity labeling of small-molecule-binding proteins by DNA-templated chemistry.Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopyLabel-free technologies for target identification and validationTarget validation using in-cell small molecule clickable imaging probes
P2860
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P2860
Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Fully functionalized small-mol ...... ing and target identification.
@ast
Fully functionalized small-mol ...... ing and target identification.
@en
Fully functionalized small-mol ...... ing and target identification.
@nl
type
label
Fully functionalized small-mol ...... ing and target identification.
@ast
Fully functionalized small-mol ...... ing and target identification.
@en
Fully functionalized small-mol ...... ing and target identification.
@nl
prefLabel
Fully functionalized small-mol ...... ing and target identification.
@ast
Fully functionalized small-mol ...... ing and target identification.
@en
Fully functionalized small-mol ...... ing and target identification.
@nl
P2860
P356
P1476
Fully functionalized small-mol ...... ing and target identification.
@en
P2093
Justin S Cisar
P2860
P304
10385-10388
P356
10.1021/JA304213W
P407
P577
2012-06-13T00:00:00Z