Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. - Test2 - elhamkhani - TriplyDB

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.

http://www.wikidata.org/entity/Q33224424

about

Identification of direct protein targets of small molecules Electrophilic affibodies forming covalent bonds to protein targets Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth Chemical proteomics approaches for identifying the cellular targets of natural products N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli.Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.Natural products as chemical probes Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe.Energetics-based discovery of protein-ligand interactions on a proteomic scale.Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma.Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells.How chemoproteomics can enable drug discovery and development Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.Chemistry-based functional proteomics for drug target deconvolution.Comparative proteomic profiling of human bile reveals SSP411 as a novel biomarker of cholangiocarcinoma.Streamlining chemical probe discovery: libraries of "fully functionalized" small molecules for phenotypic screening.Evidence for an alternative glycolytic pathway in rapidly proliferating cells.Target identification and mechanism of action in chemical biology and drug discovery.Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice Serological proteome analysis of dogs with breast cancer unveils common serum biomarkers with human counterparts.Proteomics study of N-acetylcysteine response in H1N1-infected cells by using mass spectrometry.Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications.A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells.Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo.Anticancer agents that counteract tumor glycolysis.New approaches to molecular cancer therapeutics.Application of activity-based probes to the study of enzymes involved in cancer progression.A clickable inhibitor reveals context-dependent autoactivation of p90 RSK Image-based evaluation of the molecular events underlying HC11 mammary epithelial cell differentiation.Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments.Senescence induction; a possible cancer therapy.Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors.The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: molecular target on cancer metabolism.Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.Natural products and their biological targets: proteomic and metabolomic labeling strategies.Proteomics revisits the cancer metabolome.Abundance- and Activity-Based Proteomics in Platelet Biology.Post-translational modifications and the Warburg effect.The role of phosphoglycerate mutase 1 in tumor aerobic glycolysis and its potential therapeutic implications.Chemical proteomic strategies for the discovery and development of anticancer drugs.

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Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.

http://www.wikidata.org/entity/Q33224424

description

2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Target discovery in small-mole ...... proteome reactivity profiling.

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Target discovery in small-mole ...... proteome reactivity profiling.

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Target discovery in small-mole ...... proteome reactivity profiling.

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Target discovery in small-mole ...... proteome reactivity profiling.

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Target discovery in small-mole ...... proteome reactivity profiling.

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Nature Biotechnology

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Target discovery in small-mole ...... proteome reactivity profiling.

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P2093

Alan Saghatelian

http://www.w3.org/2001/XMLSchema#string

Erik J Sorensen

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Michael J Evans

http://www.w3.org/2001/XMLSchema#string

P2860

Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex

Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis

Structure of human methionine aminopeptidase-2 complexed with fumagillin

Development of a mutagenesis, expression and purification system for yeast phosphoglycerate mutase. Investigation of the role of active-site His181.

Target-oriented and diversity-oriented organic synthesis in drug discovery

From knowing to controlling: a path from genomics to drugs using small molecule probes

Crystal structure of human B-type phosphoglycerate mutase bound with citrate

Target identification in chemical genetics: the (often) missing link

Why do cancers have high aerobic glycolysis?

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.

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1303-1307

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10.1038/NBT1149

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10

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23

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Benjamin Cravatt III

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2005-10-02T00:00:00Z

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7565290

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16200062

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