Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. - Test2 - elhamkhani - TriplyDB

Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden.

Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden.

http://www.wikidata.org/entity/Q34300607

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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types Dinosaurs and ancient civilizations: reflections on the treatment of cancer Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.Genetically engineered ERα-positive breast cancer mouse models.High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer.Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer.CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma.Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization.A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer.Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugs Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.The interconnectedness of cancer cell signaling.The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer.The two faces of Janus kinases and their respective STATs in mammary gland development and cancer Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias.PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis.Adaptive Immune Regulation of Mammary Postnatal Organogenesis STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis.Programmable nanoparticle functionalization for in vivo targeting.The tumor suppressor function of STAT1 in breast cancer STAT signaling in mammary gland differentiation, cell survival and tumorigenesis CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα(+) tumorigenesis.The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis.The differential interferon responses of two strains of Stat1-deficient mice do not alter susceptibility to HSV-1 and VSV in vivo.The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.The spectrum of STAT functions in mammary gland development Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.Unsuspected allies: chemotherapy teams up with immunity to fight cancer.Role of STAT1 in the breast.Pathobiology of the 129:Stat1 -/- mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype Overcoming intratumor heterogeneity of polygenic cancer drug resistance with improved biomarker integration Type III interferon is a critical regulator of innate antifungal immunity.

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P2860

Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden.

http://www.wikidata.org/entity/Q34300607

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

@ast

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

@en

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

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type

label

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

@ast

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

@en

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

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prefLabel

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

@ast

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

@en

Loss of STAT1 from mouse mamma ...... ased Neu-induced tumor burden.

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Loss of STAT1 from mouse mamma ...... eased Neu-induced tumor burden

@en

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Daisuke Yamaji

http://www.w3.org/2001/XMLSchema#string

Gertraud W Robinson

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Peter J Klover

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Ruth M Pfeiffer

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William J Muller

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P2860

Cancer immunoediting: from immunosurveillance to tumor escape

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease.

Type I interferon receptors: biochemistry and biological functions.

Cre-mediated gene deletion in the mammary gland.

Links between innate and adaptive immunity via type I interferon.

The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse

Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.

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899-905

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scholarly article

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10.1593/NEO.10716

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11

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12

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Lothar Hennighausen

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2010-11-01T00:00:00Z

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47792012

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21076615

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2978912

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