Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
about
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonistThe chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalizationThe relative potency of inverse opioid agonists and a neutral opioid antagonist in precipitated withdrawal and antagonism of analgesia and toxicityDifferential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cellsThe receptor concept: pharmacology's big ideaSome implications of receptor theory for in vivo assessment of agonists, antagonists and inverse agonistsA homotropic two-state model and auto-antagonismEnhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screeningGaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessorsPositive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medicationsTwo distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptorItraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growthConstitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonistsReal-time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation stateConstitutive activation of A(3) adenosine receptors by site-directed mutagenesisLigands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial libraryAn Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase ActivityVisualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: constitutive and ligand-induced internalizationIdentification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor.Opioid receptor signalling mechanisms.Salt bridge integrates GPCR activation with protein traffickingModulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery.The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.Structure and regulation of opioid receptors.Inverse agonism and its therapeutic significance.Protean agonism at histamine H3 receptors in vitro and in vivoGenetic variations in human G protein-coupled receptors: implications for drug therapy.Drug analysis based on signaling responses to G-protein-coupled receptors.A Pluridimensional View of Biased Agonism.The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor.Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptorCan intellectualism stifle scientific discovery?Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide-gated channelsOpioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependenceLoss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.The role of opioid antagonist efficacy and constitutive opioid receptor activity in the opioid withdrawal syndrome in mice'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?
P2860
Q24306565-D7B405F3-4F40-4EC6-ABC5-B53E1DE62A49Q24337078-D0C5B4E8-34D6-4133-8DD6-AF5A1D208721Q24647249-F98AC159-A813-47C4-921F-5FF6883EA699Q24650065-168CF17B-F4E9-4EE6-89A6-14DE5514AE92Q24670242-6867520E-B89C-44A5-8905-D41FA4E58E01Q24671847-72CCB3F5-4A58-43E6-AE7D-1817DEF7110BQ24795064-F66302E2-8F21-40E1-AFAE-23BCE93240F4Q24804972-1875F6AA-7573-4739-8EBD-7CCDDAD8837EQ27005640-58C7F04D-6CA4-4ABF-9F03-112C1E3722B7Q27027736-03B27228-FA06-4627-88C2-B476C341E83BQ27667675-5E7A31E8-6312-4D03-A1D4-474050CB49CBQ28279473-F5CB56DF-4F62-4510-905A-48CEC39B81F8Q28343629-EFB079F0-2C25-457C-9D06-6177216C613CQ28346724-AA71C31A-8CBF-4BF2-82DB-18E02AE9001EQ28366534-AE271664-4B88-46BA-9CF6-111D9C397D18Q28372894-0FC1C8A1-7AC2-4B5E-83AB-AFE03DC55B77Q28553493-FDBCC26E-85F1-4FC9-8B32-F9F2BC443945Q28575154-7621C51D-CFD5-44FD-8849-39CDF3AF3E6EQ33651029-0D186E59-8B34-4755-AFF6-EB2267A98341Q33687022-62ABB7C1-C091-482D-9FE3-7A6B39110A13Q33732720-0A67831A-F671-4FF6-8A18-C3743F799EF5Q33862053-3535DBC9-F17C-45BC-849A-0753B49FF473Q33865332-9C45B460-CDB9-4DC9-B842-DBFCA7F67241Q33898777-E1D39540-270D-4797-8F8F-44057F5F5D48Q33910425-5B18ABC0-91D7-4394-B70C-0028BC1D105AQ34136307-B487BF9B-EDAD-4346-9303-72076E33A293Q34226789-D23A79C6-318C-4C89-A566-C4CF7C126950Q34228615-3F65BC90-9AA7-40E3-B266-878F71520C80Q34461998-01371245-998F-4A00-A21C-31DCB2A4ECF1Q34470781-7B8A883E-5329-48B4-AFA6-7647920387B0Q34540545-FFF2EE3D-516C-40B1-B37A-4EA7F645567DQ34734743-96F6C09B-29F4-4582-A13D-FA75869CD707Q34770179-1F74FB23-4935-47B6-AB87-F83DBC584D86Q34932240-A856C581-4DB7-4BF6-AF60-E56C58F83BB6Q34957285-856CC288-1AD7-4408-94CA-75561D37B889Q35018179-0F321EE2-A802-4A9A-A5A0-9708869CE7EEQ35049029-D51C1E2A-7578-4C6F-B39A-42B5162C28B5Q35108528-1BB0E16C-6BEA-4436-8A57-A95003E00C31Q35165171-E90779FA-4E45-4849-ADFF-FEFDE52063FEQ35210020-03F71A88-D63A-4699-A125-05B945BC50FB
P2860
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
description
1989 nî lūn-bûn
@nan
1989 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Antagonists with negative intr ...... upled to GTP-binding proteins.
@ast
Antagonists with negative intr ...... upled to GTP-binding proteins.
@en
Antagonists with negative intr ...... upled to GTP-binding proteins.
@nl
type
label
Antagonists with negative intr ...... upled to GTP-binding proteins.
@ast
Antagonists with negative intr ...... upled to GTP-binding proteins.
@en
Antagonists with negative intr ...... upled to GTP-binding proteins.
@nl
prefLabel
Antagonists with negative intr ...... upled to GTP-binding proteins.
@ast
Antagonists with negative intr ...... upled to GTP-binding proteins.
@en
Antagonists with negative intr ...... upled to GTP-binding proteins.
@nl
P2860
P356
P1476
Antagonists with negative intr ...... upled to GTP-binding proteins.
@en
P2860
P304
P356
10.1073/PNAS.86.19.7321
P407
P577
1989-10-01T00:00:00Z