A medicinal chemistry perspective on artemisinin and related endoperoxides.
about
Artemisinin-resistant malaria: research challenges, opportunities, and public health implicationsPlasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug targetEndoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffoldArtemisinin Action and Resistance in Plasmodium falciparumAnti-plasmodium activity of angiotensin II and related synthetic peptidesAntimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria modelReal-time imaging of the intracellular glutathione redox potential in the malaria parasite Plasmodium falciparumNovel multiarm polyethylene glycol-dihydroartemisinin conjugates enhancing therapeutic efficacy in non-small-cell lung cancer.Reaction of artemisinin with haemoglobin: implications for antimalarial activity.Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparumArtemisinin directly targets malarial mitochondria through its specific mitochondrial activation.Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activitiesComparative analysis of the safety and tolerability of fixed-dose artesunate/amodiaquine versus artemether/lumefantrine combinations for uncomplicated falciparum malaria in pregnancy: a randomized open label study.Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells.Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii.The antimalarial drug artemisinin alkylates heme in infected mice.Recent progress in the development of anti-malarial quinolones.Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5Natural products: a continuing source of novel drug leadsThe lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesNox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cellsEfficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery.Self-assembled targeted nanoparticles based on transferrin-modified eight-arm-polyethylene glycol-dihydroartemisinin conjugate.Malaria biology and disease pathogenesis: insights for new treatments.Plasmodium drug targets outside the genetic control of the parasite.Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.Artemisinins.Drug delivery to the malaria parasite using an arterolane-like scaffold.Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probesArtemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins.Emerging issues in traditional Chinese medicine.The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents.Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds.Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.Recent advances in the search for antiviral agents against human papillomaviruses.Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivityFerrous iron-dependent delivery of therapeutic agents to the malaria parasite.Drug discovery and development for neglected parasitic diseases.Timing is everything for artemisinin action
P2860
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P2860
A medicinal chemistry perspective on artemisinin and related endoperoxides.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@ast
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@en
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@nl
type
label
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@ast
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@en
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@nl
prefLabel
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@ast
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@en
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@nl
P356
P1476
A medicinal chemistry perspective on artemisinin and related endoperoxides.
@en
P2093
Gary H Posner
Paul M O'Neill
P304
P356
10.1021/JM030571C
P407
P577
2004-06-01T00:00:00Z