Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. - Test2 - elhamkhani - TriplyDB

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.

http://www.wikidata.org/entity/Q34693880

about

Artemisinin: discovery from the Chinese herbal garden Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?Designing the next generation of medicines for malaria control and eradication Recent advances in malaria drug discovery Using genetic methods to define the targets of compounds with antimalarial activity Malaria in South America: a drug discovery perspective Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Antimalarial drug discovery - approaches and progress towards new medicines.A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery Mathematical Modelling to Guide Drug Development for Malaria Elimination Artemisinin Action and Resistance in Plasmodium falciparum Integrated dataset of screening hits against multiple neglected disease pathogens Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease Anticancer properties of distinct antimalarial drug classes Evaluation of antimalarial activity and toxicity of a new primaquine prodrug Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens A novel multiple-stage antimalarial agent that inhibits protein synthesis In vivo curative and protective potential of orally administered 5-aminolevulinic acid plus ferrous ion against malaria.Recent highlights in anti-protozoan drug development and resistance research.Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro.Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.Fixed dose combination of arterolane and piperaquine: a newer prospect in antimalarial therapy Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.Altered temporal response of malaria parasites determines differential sensitivity to artemisinin The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax Antimalarial compounds in Phase II clinical development.Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery.The discovery of artemisinin and the Nobel Prize in Physiology or Medicine Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.Malaria biology and disease pathogenesis: insights for new treatments.Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations.Modelling the time course of antimalarial parasite killing: a tour of animal and human models, translation and challenges Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model.

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P2860

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.

http://www.wikidata.org/entity/Q34693880

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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PNAS.1015762108

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Proceedings of the National Academy of Sciences of the United States of America

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Synthetic ozonide drug candida ...... cure of uncomplicated malaria.

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Christian Scheurer

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David M Shackleford

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Francis C K Chiu

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Heinrich Urwyler

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Hugues Matile

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Ian C Bathurst

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J Carl Craft

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Jonathan L Vennerstrom

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Julia Morizzi

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Kamaraj Sriraghavan

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P2860

Qinghaosu (Artemisinin): The Price of Success

Artemisinin resistance: current status and scenarios for containment

Antimalarial drug resistance

Identification of an antimalarial synthetic trioxolane drug development candidate

Artemisinins target the SERCA of Plasmodium falciparum

Assessment of the pharmacodynamic properties of antimalarial drugs in vivo

The antimalarial drug artemisinin alkylates heme in infected mice.

A medicinal chemistry perspective on artemisinin and related endoperoxides.

Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action.

Medical need, scientific opportunity and the drive for antimalarial drugs.

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4400-4405

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10.1073/PNAS.1015762108

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11

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108

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William N. Charman

Susan A. Charman

Jacques Chollet

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2011-02-07T00:00:00Z

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49817062

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21300861

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3060245

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