Hypoxia links ATR and p53 through replication arrest. - Test2 - elhamkhani - TriplyDB

Hypoxia links ATR and p53 through replication arrest.

Hypoxia links ATR and p53 through replication arrest.

http://www.wikidata.org/entity/Q34324309

about

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.Chromosomal instability at common fragile sites in Seckel syndrome DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation Hypoxia and metabolic adaptation of cancer cells DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Roles of Chk1 in cell biology and cancer therapy SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase.Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosis A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication DNA instability at chromosomal fragile sites in cancer HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia.Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells.Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system.The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection.Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.RecQ family helicases: roles as tumor suppressor proteins.Reciprocal influence of the p53 and the hypoxic pathways Targeting lung cancer through inhibition of checkpoint kinases.Infection, inflammation, and gastrointestinal cancer.Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.Modeling the interplay between the HIF-1 and p53 pathways in hypoxia Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids Mechanisms of early brain injury after subarachnoid hemorrhage.Mechanisms of chemoresistance in cancer stem cells.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.Activation of Polo-like kinase 3 by hypoxic stresses.Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.Histone H2AX is integral to hypoxia-driven neovascularization.

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P2860

Hypoxia links ATR and p53 through replication arrest.

http://www.wikidata.org/entity/Q34324309

description

2002 nî lūn-bûn

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2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Hypoxia links ATR and p53 through replication arrest.

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Hypoxia links ATR and p53 through replication arrest.

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Hypoxia links ATR and p53 through replication arrest.

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type

label

Hypoxia links ATR and p53 through replication arrest.

@ast

Hypoxia links ATR and p53 through replication arrest.

@en

Hypoxia links ATR and p53 through replication arrest.

@nl

prefLabel

Hypoxia links ATR and p53 through replication arrest.

@ast

Hypoxia links ATR and p53 through replication arrest.

@en

Hypoxia links ATR and p53 through replication arrest.

@nl

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MCB.22.6.1834-1843.2002

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Molecular and Cellular Biology

P1476

Hypoxia links ATR and p53 through replication arrest.

@en

P2093

Amato J Giaccia

http://www.w3.org/2001/XMLSchema#string

Ester M Hammond

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Mary Jo Dorie

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Nicholas C Denko

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Robert T Abraham

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P2860

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Mdm2 promotes the rapid degradation of p53

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

Regulation of p53 stability by Mdm2

p53, the cellular gatekeeper for growth and division

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

The many substrates and functions of ATM

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scholarly article

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10.1128/MCB.22.6.1834-1843.2002

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