Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. - Test2 - elhamkhani - TriplyDB

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.

http://www.wikidata.org/entity/Q34324645

about

Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine Molecular Aspects of Head and Neck Cancer Therapy Comprehensive genomic characterization of head and neck squamous cell carcinomas Genomic and molecular characterization of esophageal squamous cell carcinoma Genomic profiling reveals mutational landscape in parathyroid carcinomas Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities Characterization of genetic aberrations in a single case of metastatic thymic adenocarcinoma.Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline.Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers.Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies Sleeping giants: emerging roles for the fat cadherins in health and disease.Whole-exome sequencing of primary plasma cell leukemia discloses heterogeneous mutational patterns.FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation.The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups.Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours.Unraveling the molecular genetics of head and neck cancer through genome-wide approaches Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma Mutational spectrum of adult T-ALL Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.FAT1 mutations cause a glomerulotubular nephropathy Genetic Landscape of Human Papillomavirus-Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors.Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.FAT4 functions as a tumour suppressor in gastric cancer by modulating Wnt/β-catenin signalling.NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma.Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity.FAT1: a potential target for monoclonal antibody therapy in colon cancer.Association between FAT1 mutation and overall survival in patients with human papillomavirus-negative head and neck squamous cell carcinoma Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA-microRNA regulatory network in nasopharyngeal carcinoma model systems.Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness.Shaping the nervous system: role of the core planar cell polarity genes.Beyond E-cadherin: roles of other cadherin superfamily members in cancer.Defining the genomic landscape of head and neck cancers through next-generation sequencing.Novel treatments for head and neck squamous cell carcinoma: preclinical identification and clinical investigation.

P2860

Q26768533-8BF408C2-88C5-4743-98A0-061B917803AE Q26796673-0C2EC364-0D93-462C-B30C-F50DCC24F16C Q28082815-6A5E393E-D670-4FA5-BD58-704F57876D9E Q28256121-C19869C2-6AF9-4B28-85F2-1A484BF74737 Q28657686-F95BCF84-80EB-451D-ADBA-E2F47E98175E Q30360213-8A87871C-B641-4248-A50B-A7EB7461B2EA Q33588151-E60C8A10-0CB8-469F-AFDB-2B7A1C235D58 Q33691435-FF771E2C-A4A0-4FE9-BD26-95A145553403 Q33713669-EE3750A1-C7E1-4F47-9253-7BC743BECD35 Q33916786-A398A578-76CA-49A5-9058-52A5209B7841 Q34084254-F63C06FA-D323-43BF-8FFB-AFB1867E7DB7 Q34159739-0BFC1ED2-05AD-4600-AB03-CF4715D8D777 Q34347563-2C949240-DEC5-440B-BC06-E419BA979FAF Q34479418-1A5A9EEB-BE57-4571-825D-1E23363A42B3 Q34481977-B669C4EC-5733-43CC-A791-7415F0F0633B Q34619156-0EEA2B34-57B6-45A2-ADDB-74FA0864F7F5 Q34658030-7DF39E99-B689-4BA0-8DFB-532CA7CF0C85 Q34832999-4961A301-4D76-439C-ACEA-3185ED5F7388 Q35025009-1CA436DA-BB77-41EA-9DDC-385823E29BF7 Q35266369-C9E1B104-D620-4F07-9582-8B2A3BE69DB5 Q35550090-E0F353F3-4E09-4EEE-A2E0-A8E222482FC2 Q35752935-B4E868CC-3674-4FFB-80DA-805A95448FE2 Q35793534-66C68F1F-32E7-4595-8DF6-779BD11C6042 Q35932259-ABE18D9E-503A-436B-8E78-6FAA8EA9689E Q36100833-7D3A0E9E-4EB0-48E3-B792-E7866A426353 Q36322776-50780F8F-5DC4-40E5-A312-AD9A8C4B58C9 Q36432085-DE4BD017-612A-4037-A049-A14D25F974E6 Q36580224-7C910DD7-90A5-471E-8785-2F7382872039 Q36646352-ABFC9808-63F7-400C-BA64-C43C71AF9566 Q36771967-343EF771-8C82-4CCB-AA3B-4219F31E3FB2 Q37061340-9E4ECA8B-4B74-40B1-9BAC-7823F1ADDD66 Q37345682-D1C19DF4-6587-40A2-B35C-085569B7CB85 Q37381036-33A1F37A-4F8A-4C7F-BAEF-AB787FB284A5 Q37395251-660F92A5-297F-4444-8035-070CF4DEC662 Q37534984-C5ACCFD2-6F8E-4D7D-812E-DBDF9DBC7E5F Q37697850-D0FEC995-3E3E-4C6A-BB31-A5C6AC167017 Q38120492-316B6318-C275-4781-9336-5B67BB16DCF5 Q38179961-AAB36252-C276-483A-A4E8-17B93FE78B7F Q38203938-265F7A55-F866-4133-B697-D8A60605B020 Q38221292-14D4907F-86EE-49F3-9B40-B66611EF74BF

P2860

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.

http://www.wikidata.org/entity/Q34324645

description

2013 nî lūn-bûn

@nan

2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@ast

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@en

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@nl

type

label

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@ast

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@en

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@nl

prefLabel

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@ast

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@en

Recurrent somatic mutation of ...... ds to aberrant Wnt activation.

@nl

P1433

Q34324645-51D20656-DCCA-4B25-A122-29ECDD0BC354

P1476

Q34324645-E3DD48E7-A4B8-463C-A833-2E2FC586E28A

P2093

Q34324645-1F7F71E5-D7C5-44E4-8AE4-92671591D493

Q34324645-2171F9A0-9722-4616-A2AB-34BBAE527F91

Q34324645-244B7B15-352E-4EC9-9EDD-032BEB5CA6A7

Q34324645-344A0616-80A4-4D5A-9F39-3E2879FB28A7

Q34324645-3FCF419B-514C-471C-90AB-17D92D262DDA

Q34324645-6F960D27-ACD0-4CC4-97FF-9828360080A2

Q34324645-74295B80-6B50-4BEC-B0D5-4406D601BBDB

Q34324645-7A8D044B-5854-40A8-A527-E6042BDD3F99

Q34324645-980A5BE5-72D0-4AC4-8B73-FF97EBEF51D6

Q34324645-9C683D62-9903-4017-B5E6-D2DFCF0DFAFA

P2860

Q34324645-07AE4A9B-5A3A-45B1-913E-662023F7F27D

Q34324645-07B67D0C-9E41-4C84-B468-14449466807A

Q34324645-091F9A15-EBCA-4D56-BF8D-7293921AC36E

Q34324645-0ADD40F1-B510-457B-B0AA-D4A363111791

Q34324645-0B11E46E-F76B-4E43-9929-64929A6E5904

Q34324645-0C0AF4D1-D848-476A-9903-32ED51E01F3C

Q34324645-0CF5D81F-232D-4CE2-811C-6A9BA6C8041C

Q34324645-12B9BA35-31DD-435D-A8C5-DFE53C240E6E

Q34324645-151A3512-475F-427F-B7A3-BE0087DAD8D0

Q34324645-171D91A5-BD7D-4D04-8B90-4FAE536E07DD

P2888

Q34324645-166DA5B2-7E6E-47B6-B0FC-DD79E5EFBCFF

P304

Q34324645-0AAECCD1-CEA6-4BED-B63A-EDCF5449FD1C

P31

Q34324645-B3C920FF-E64A-4AD4-9636-B60CC67126BC

P356

Q34324645-FE9515F0-84D3-43D4-BCB1-4B8998531DA6

P407

Q34324645-E5D0C73A-668A-473B-83CD-27F1CDB04A6F

P433

Q34324645-4D733898-109B-406F-B12A-944551E0788E

P478

Q34324645-5C31B032-2545-4CE8-A119-1D551E779E22

P50

Q34324645-13B71F6F-E972-47AE-BF74-AE5188022937

Q34324645-6BFBD624-01AB-462D-91C2-18CAE591CB47

Q34324645-80E10663-9972-4A11-88A9-D568C805D2F4

Q34324645-953D8955-BCBD-4054-8E65-B41C143E165D

Q34324645-D87E56B9-C9D4-4CBD-A35C-FEC28EA6FCB0

Q34324645-F8765BDF-B16D-4A21-911C-3AD6EB8B0347

P577

Q34324645-DD9DFA8F-7234-4810-B838-83B072E95A70

P5875

Q34324645-0545C6B6-2116-43B5-82BE-704B32C05096

P698

Q34324645-875DA592-113E-4742-B2C1-2F626C47505B

P932

Q34324645-2C658C4F-EFF2-442C-B86F-B10B4357DCC6

P356

P1433

Nature Genetics

P1476

Recurrent somatic mutation of ...... ads to aberrant Wnt activation

@en

P2093

Andrew M Kaufman

http://www.w3.org/2001/XMLSchema#string

Bhuvanesh Singh

http://www.w3.org/2001/XMLSchema#string

David Solit

http://www.w3.org/2001/XMLSchema#string

Deepa Ramaswami

http://www.w3.org/2001/XMLSchema#string

Efsevia Vakiani

http://www.w3.org/2001/XMLSchema#string

Ingo K Mellinghoff

http://www.w3.org/2001/XMLSchema#string

Luc G T Morris

http://www.w3.org/2001/XMLSchema#string

Luke Peng

http://www.w3.org/2001/XMLSchema#string

Paul S Mischel

http://www.w3.org/2001/XMLSchema#string

Phillip Paty

http://www.w3.org/2001/XMLSchema#string

P2860

U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma

Identification of c-MYC as a target of the APC pathway

Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization

Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

P2888

P304

253-261

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NG.2538

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

45

http://www.w3.org/2001/XMLSchema#string

P50

Kasthuri Kannan

P577

2013-01-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

235376172

http://www.w3.org/2001/XMLSchema#string

P698

23354438

http://www.w3.org/2001/XMLSchema#string

P932

3729040

http://www.w3.org/2001/XMLSchema#string