about
Structural biology and chemistry of protein arginine methyltransferasesChemical probes of histone lysine methyltransferasesChemical biology approaches for the study of apicomplexan parasitesCETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar AffinitiesFragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration AnalysisFirst-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosisInvestigating Apoptozole as a Chemical Probe for HSP70 InhibitionApplications of chemogenomic library screening in drug discoveryPotent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibitionDiscovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2Structure-Based Design of an in Vivo Active Selective BRD9 InhibitorTubulin is a molecular target of the Wnt-activating chemical probeA cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)Promiscuity and the conformational rearrangement of drug-like molecules: insight from the protein data bank.Prostanoid receptor EP2 as a therapeutic targetTetrazine ligation for chemical proteomics.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.The promise and peril of chemical probes.Selective inhibitors of protein methyltransferasesMitigating risk in academic preclinical drug discovery.Click chemistry patents and their impact on drug discovery and chemical biology.Cell permeable affinity- and activity-based probes.Advances in discovering small molecules to probe protein function in a systems context.Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac DifferentiationAdvances in measuring single-cell pharmacology in vivo.Chromodomain Ligand Optimization via Target-Class Directed Combinatorial RepurposingSmall Molecules in Development for the Treatment of Spinal Muscular Atrophy.A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA DamageSmall Molecule Inhibitors of Protein Arginine Methyltransferases.Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.Understanding and applying tyrosine biochemical diversity.TAK1 selective inhibition: state of the art and future opportunities.Addressing the right targets in oncology: challenges and alternative approaches.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Target validation using chemical probes.
@ast
Target validation using chemical probes.
@en
Target validation using chemical probes.
@nl
type
label
Target validation using chemical probes.
@ast
Target validation using chemical probes.
@en
Target validation using chemical probes.
@nl
prefLabel
Target validation using chemical probes.
@ast
Target validation using chemical probes.
@en
Target validation using chemical probes.
@nl
P2860
P356
P1476
Target validation using chemical probes.
@en
P2093
Eugene L Piatnitski Chekler
Mark E Bunnage
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1197
P50
P577
2013-04-01T00:00:00Z