Active mutants of the human p38alpha mitogen-activated protein kinase.
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Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailThe p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38αPhosphorylation of p68 RNA helicase by p38 MAP kinase contributes to colon cancer cells apoptosis induced by oxaliplatin.Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammationp38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinasesInhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids.Stress-mediated p38 activation promotes somatic cell reprogramming.ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo.Tighter αC-helix-αL16-helix interactions seem to make p38α less prone to activation by autophosphorylation than Hog1.p38β Mitogen-Activated Protein Kinase Modulates Its Own Basal Activity by Autophosphorylation of the Activating Residue Thr180 and the Inhibitory Residues Thr241 and Ser261Analysis of crystal structure of Arabidopsis MPK6 and generation of its mutants with higher activity.Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation.T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificityDocking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinasePhosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.Synthetic phosphorylation of p38α recapitulates protein kinase activityConformational bias imposed by source microseeds results in structural ambiguity.Modularity of MAP kinases allows deformation of their signalling pathways.SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress.Role of Molecular Interactions and Protein Rearrangement in the Dissociation Kinetics of p38α MAP Kinase Type-I/II/III Inhibitors.Molecular mechanisms for the p38-induced cellular senescence in normal human fibroblast.Constitutively active mitogen-activated protein kinase versions reveal functions of Arabidopsis MPK4 in pathogen defense signaling.
P2860
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P2860
Active mutants of the human p38alpha mitogen-activated protein kinase.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Active mutants of the human p38alpha mitogen-activated protein kinase.
@ast
Active mutants of the human p38alpha mitogen-activated protein kinase.
@en
Active mutants of the human p38alpha mitogen-activated protein kinase.
@nl
type
label
Active mutants of the human p38alpha mitogen-activated protein kinase.
@ast
Active mutants of the human p38alpha mitogen-activated protein kinase.
@en
Active mutants of the human p38alpha mitogen-activated protein kinase.
@nl
prefLabel
Active mutants of the human p38alpha mitogen-activated protein kinase.
@ast
Active mutants of the human p38alpha mitogen-activated protein kinase.
@en
Active mutants of the human p38alpha mitogen-activated protein kinase.
@nl
P2093
P2860
P356
P1476
Active mutants of the human p38alpha mitogen-activated protein kinase.
@en
P2093
David Engelberg
Nadav Askari
Oded Livnah
Ron Diskin
P2860
P304
47040-47049
P356
10.1074/JBC.M404595200
P407
P577
2004-07-28T00:00:00Z