Targeting MYC Expression through G-Quadruplexes. - Test2 - elhamkhani - TriplyDB

Targeting MYC Expression through G-Quadruplexes.

Targeting MYC Expression through G-Quadruplexes.

http://www.wikidata.org/entity/Q34352558

about

Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)MYC on the path to cancer c-MYC-Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease.Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide.Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation.Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.Evaluation of fluorescent analogs of deoxycytidine for monitoring DNA transitions from duplex to functional structures Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression.Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription GNG Motifs Can Replace a GGG Stretch during G-Quadruplex Formation in a Context Dependent Manner Genetic and molecular alterations across medulloblastoma subgroups Extended molecular dynamics of a c-kit promoter quadruplex.Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription.Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.Strategies to Inhibit Myc and Their Clinical Applicability SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity.In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.G-register exchange dynamics in guanine quadruplexes.DNA G-quadruplex and its potential as anticancer drug target A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo.Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex.An XIST-related small RNA regulates KRAS G-quadruplex formation beyond X-inactivation.Epigenetic modification, dehydration, and molecular crowding effects on the thermodynamics of i-motif structure formation from C-rich DNA.The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.Enigmatic MYC Conducts an Unfolding Systems Biology Symphony.Learning about the functions of NME/NM23: lessons from knockout mice to silencing strategies.Targeting non-B-form DNA in living cells.Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer.G-quadruplex structures in the human genome as novel therapeutic targets.G-quadruplexes as potential therapeutic targets for embryonal tumors.

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P2860

Targeting MYC Expression through G-Quadruplexes.

http://www.wikidata.org/entity/Q34352558

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Targeting MYC Expression through G-Quadruplexes.

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Targeting MYC Expression through G-Quadruplexes.

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Targeting MYC Expression through G-Quadruplexes.

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Targeting MYC Expression through G-Quadruplexes.

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Targeting MYC Expression through G-Quadruplexes.

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Targeting MYC Expression through G-Quadruplexes.

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Targeting MYC Expression through G-Quadruplexes.

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Laurence H Hurley

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Tracy A Brooks

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P2860

The Hallmarks of Cancer

Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis

Prevalence of quadruplexes in the human genome.

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation

Heterogeneous nuclear ribonucleoprotein K is a transcription factor

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents.

Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)

Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter

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641-649

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scholarly article

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10.1177/1947601910377493

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6

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1

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2010-06-01T00:00:00Z

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49641237

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21113409

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2992328

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