Human high-altitude adaptation: forward genetics meets the HIF pathway. - Test2 - elhamkhani - TriplyDB

Human high-altitude adaptation: forward genetics meets the HIF pathway.

Human high-altitude adaptation: forward genetics meets the HIF pathway.

http://www.wikidata.org/entity/Q34360748

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Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases The human physiological impact of global deoxygenation Neuronal responses to stress and injury in C. elegans Tracing the peopling of the world through genomics Using Population and Comparative Genomics to Understand the Genetic Basis of Effector-Driven Fungal Pathogen Evolution Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia.Evolutionary history of Tibetans inferred from whole-genome sequencing.Metabolic basis to Sherpa altitude adaptation 2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Going global by adapting local: A review of recent human adaptation Altitude Adaptation: A Glimpse Through Various Lenses.Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL).Gene Co-Expression Network Analysis Unraveling Transcriptional Regulation of High-Altitude Adaptation of Tibetan Pig.Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia Wide distribution and altitude correlation of an archaic high-altitude-adaptive EPAS1 haplotype in the Himalayas The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders.The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia.Physiological Adjustments and Circulating MicroRNA Reprogramming Are Involved in Early Acclimatization to High Altitude in Chinese Han Males.Energy metabolism and the high-altitude environment.Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization.Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.Geographical variation in the progression of type 2 diabetes in Peru: The CRONICAS Cohort Study.Genetics of human origin and evolution: high-altitude adaptations.Auxological perspectives on 'growth' in DOHaD.Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension.The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks.The effects of moderate intensity training in a hypoxic environment on transcriptional responses in Thoroughbred horses.Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling.Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations.Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity.Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult.High-altitude adaptation in humans: from genomics to integrative physiology.Hypoxia-Inducible Factors and Cancer.Human Genetic Adaptation to High Altitudes: Current Status and Future Prospects.Detecting gene subnetworks under selection in biological pathways.Intracellular iron and heme trafficking and metabolism in developing erythroblasts.Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes.

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P2860

Human high-altitude adaptation: forward genetics meets the HIF pathway.

http://www.wikidata.org/entity/Q34360748

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2014 nî lūn-bûn

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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Human high-altitude adaptation: forward genetics meets the HIF pathway.

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Genes & Development

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Human high-altitude adaptation: forward genetics meets the HIF pathway

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Abigail W Bigham

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P2860

Genetic variants in EPAS1 contribute to adaptation to high-altitude hypoxia in Sherpas

Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data

Genetic adaptation to high altitude in the Ethiopian highlands

On the origin of Tibetans and their genetic basis in adapting high-altitude environments

Experimental selection of hypoxia-tolerant Drosophila melanogaster

The tiger genome and comparative analysis with lion and snow leopard genomes

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

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