"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally - Test2 - elhamkhani - TriplyDB

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

http://www.wikidata.org/entity/Q34369829

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Stathmin is dispensable for tumor onset in mice MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis p53 Stabilization and accumulation induced by human vaccinia-related kinase 1 Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol The DNA-damage response in human biology and disease TAp63 prevents premature aging by promoting adult stem cell maintenance Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor Two faces of p53: aging and tumor suppression Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer Modeling the study of DNA damage responses in mice Systemic DNA damage responses in aging and diseases Puma is required for p53-induced depletion of adult stem cells An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis Evolutionary foundations for cancer biology Peto's Paradox: evolution's prescription for cancer prevention The tumour suppressor CYLD regulates the p53 DNA damage response Modulation of mammalian life span by the short isoform of p53.The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.Antagonistic pleiotropy and p53.Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal.Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity A common biological mechanism in cancer and Alzheimer's disease?It's all about balance: p53 and aging P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.The dichotomy of p53 regulation by noncoding RNAs.SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53.Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells.p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo.Peto's Paradox: how has evolution solved the problem of cancer prevention?Pathologies associated with the p53 response.Effects of age and heart failure on human cardiac stem cell function.Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association.Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence.

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

http://www.wikidata.org/entity/Q34369829

description

2002 nî lūn-bûn

@nan

2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

"Super p53" mice exhibit enhan ...... mor resistant and age normally

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

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type

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

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The EMBO Journal

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"Super p53" mice exhibit enhan ...... mor resistant and age normally

@en

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Isabel García-Cao

http://www.w3.org/2001/XMLSchema#string

Jean-Claude Weill

http://www.w3.org/2001/XMLSchema#string

Juan Martín-Caballero

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Juana M Flores

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Luis M Criado

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Marta García-Cao

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Peter Klatt

http://www.w3.org/2001/XMLSchema#string

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The Hallmarks of Cancer

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Surfing the p53 network

Transgenic monkeys produced by retroviral gene transfer into mature oocytes

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Tumor spectrum analysis in p53-mutant mice

Radiation-induced cell cycle arrest compromised by p21 deficiency

p53 is required for radiation-induced apoptosis in mouse thymocytes

p53 mutant mice that display early ageing-associated phenotypes

The INK4A/ARF locus and its two gene products.

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6225-6235

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scholarly article

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10.1093/EMBOJ/CDF595

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22

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21

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2002-11-01T00:00:00Z

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8170362

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12426394

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137187

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