about
Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinasesDown-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferationAn adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl bindingProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesCD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-CblNegative regulation of Lck by Cbl ubiquitin ligaseRuk is ubiquitinated but not degraded by the proteasomeDrosophila cbl is essential for control of cell death and cell differentiation during eye developmentTargeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulationThe N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.Rapid ubiquitination of Syk following GPVI activation in plateletsCatalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.Activating CBL mutations are associated with a distinct MDS/MPN phenotype.Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation.Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loopRoles of E3 ubiquitin ligases in cell adhesion and migration.D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis.E3 ubiquitin ligase Cbl-b in innate and adaptive immunity.c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice.Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signalingCrk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.Cbl-3-deficient mice exhibit normal epithelial developmentInactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance.TULA-family proteins: a new class of cellular regulators.Cbl proteins in platelet activation.E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.Cbl-family proteins as regulators of cytoskeleton-dependent phenomena.Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies.Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.Mutations of c-Cbl in myeloid malignanciesRecent advances of adapter proteins in the regulation of heart diseases.CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis.Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer.Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Beyond the RING: CBL proteins as multivalent adapters.
@ast
Beyond the RING: CBL proteins as multivalent adapters.
@en
Beyond the RING: CBL proteins as multivalent adapters.
@nl
type
label
Beyond the RING: CBL proteins as multivalent adapters.
@ast
Beyond the RING: CBL proteins as multivalent adapters.
@en
Beyond the RING: CBL proteins as multivalent adapters.
@nl
prefLabel
Beyond the RING: CBL proteins as multivalent adapters.
@ast
Beyond the RING: CBL proteins as multivalent adapters.
@en
Beyond the RING: CBL proteins as multivalent adapters.
@nl
P2093
P2860
P356
P1433
P1476
Beyond the RING: CBL proteins as multivalent adapters.
@en
P2093
A M Teckchandani
A Y Tsygankov
E A Feshchenko
G Swaminathan
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204781
P407
P577
2001-10-01T00:00:00Z
P6179
1006240713