The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice
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Science gone translational: the OX40 agonist storyAcute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.CD8 T cells use IFN-γ to protect against the lethal effects of a respiratory poxvirus infection.Strikingly poor CD8+ T-cell immunogenicity of vaccinia virus strain MVA in BALB/c mice.Transcriptional control of effector and memory CD8+ T cell differentiation.CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in miceOX40 facilitates control of a persistent virus infection.A stimulating way to improve T cell responses to poxvirus-vectored vaccinesRegulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity.B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization.CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA.Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of miceTargeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infectionDispensable role for 4-1BB and 4-1BBL in development of vaccinia virus-specific CD8 T cellsAn alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling.Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens.CD8 T cells are essential for recovery from a respiratory vaccinia virus infection.CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.T Cell Vaccinology: Beyond the Reflection of Infectious ResponsesTranscription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function during Poxvirus InfectionTissue-specific programming of memory CD8 T cell subsets impacts protection against lethal respiratory virus infection.Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function.OX40:OX40L axis: emerging targets for improving poxvirus-based CD8(+) T-cell vaccines against respiratory virusesThe fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes.The role of belataceptin transplantation: results and implications of clinical trials in the context of other new biological immunosuppressant agents.Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse.The contextual role of TNFR family members in CD8(+) T-cell control of viral infections.The TNF family in T cell differentiation and function--unanswered questions and future directions.HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity.OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection.The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.CD27 costimulation contributes substantially to the expansion of functional memory CD8(+) T cells after peptide immunization.CD70 encoded by modified vaccinia virus Ankara enhances CD8 T cell dependent protective immunity in MHC class II-deficient mice.Inflammatory monocytes contribute to the persistence of CXCR3hi CX3CR1lo circulating and lung-resident memory CD8+ T cells following respiratory virus infection.The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection.
P2860
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P2860
The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice
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2010 nî lūn-bûn
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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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The TNFR family members OX40 a ...... ective T cell vaccines in mice
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The TNFR family members OX40 a ...... ective T cell vaccines in mice
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The TNFR family members OX40 a ...... ective T cell vaccines in mice
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The TNFR family members OX40 a ...... ective T cell vaccines in mice
@ast
The TNFR family members OX40 a ...... ective T cell vaccines in mice
@en
The TNFR family members OX40 a ...... ective T cell vaccines in mice
@nl
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The TNFR family members OX40 a ...... ective T cell vaccines in mice
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The TNFR family members OX40 a ...... ective T cell vaccines in mice
@en
The TNFR family members OX40 a ...... ective T cell vaccines in mice
@nl
P2093
P2860
P356
P1476
The TNFR family members OX40 a ...... ective T cell vaccines in mice
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P2093
Geoffrey L Smith
Hideo Yagita
Jannie Borst
Michael Croft
Rachel Flynn
Ramon Arens
Shahram Salek-Ardakani
P2860
P304
P356
10.1172/JCI42056
P407
P577
2010-12-22T00:00:00Z