Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice
about
Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potentialAcute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses.Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.Regulation of tissue-dependent differences in CD8+ T cell apoptosis during viral infection.TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin's lymphoma.OX40 facilitates control of a persistent virus infection.Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2.OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.Expression of the immune regulation antigen CD70 in osteosarcoma.Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinomaT cell vaccinology: exploring the known unknowns.CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.Viral Persistence Induces Antibody Inflation without Altering Antibody AvidityCD70 is downregulated by interaction with CD27.Macrophage and T cell produced IL-10 promotes viral chronicityThe fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes.The contextual role of TNFR family members in CD8(+) T-cell control of viral infections.Therapeutic targeting of CD70 and CD27.The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines.CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy.The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma.Terminally differentiated CD8+ T cells and CD57-FOXP3+CD8+ T cells are highly associated with the efficacy of immunotherapy using activated autologous lymphocytes.CD57 ratio as a convenient and useful immunological and prognostic parameter for stage IV carcinoma.
P2860
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P2860
Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice
description
2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2011 թվականի ապրիլին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Opposing effects of CD70 costi ...... ngitis virus infection of mice
@ast
Opposing effects of CD70 costi ...... ngitis virus infection of mice
@en
type
label
Opposing effects of CD70 costi ...... ngitis virus infection of mice
@ast
Opposing effects of CD70 costi ...... ngitis virus infection of mice
@en
prefLabel
Opposing effects of CD70 costi ...... ngitis virus infection of mice
@ast
Opposing effects of CD70 costi ...... ngitis virus infection of mice
@en
P2093
P2860
P356
P1433
P1476
Opposing effects of CD70 costi ...... ngitis virus infection of mice
@en
P2093
Ata Ur Rasheed
Hideo Yagita
Pablo Penaloza-MacMaster
Rafi Ahmed
Smita S Iyer
P2860
P304
P356
10.1128/JVI.02205-10
P407
P577
2011-04-20T00:00:00Z