Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
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Strategically targeting MYC in cancerTargeting cancer with kinase inhibitorsStructure of the Human Protein Kinase ZAK in Complex with VemurafenibTFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer TreatmentEngineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA StabilizationMediator kinase inhibition further activates super-enhancer-associated genes in AMLdbSUPER: a database of super-enhancers in mouse and human genomeDiscovery of host-targeted covalent inhibitors of dengue virusAssessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesIdentification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assayPositive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse ElectrophilesCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsSmall Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven CancersEssential role of endogenous prolactin and CDK7 in estrogen-induced upregulation of the prolactin receptor in breast cancer cellsSite-specific regulation of histone H1 phosphorylation in pluripotent cell differentiationDetermining Cysteines Available for Covalent Inhibition Across the Human Kinome.A mathematical theory of the transcription repression (TR) therapy of cancer - whether and how it may work.CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinomaCDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitorThe history and future of targeting cyclin-dependent kinases in cancer therapy.CDK7-dependent transcriptional addiction in triple-negative breast cancer.SEA: a super-enhancer archive.Models of human core transcriptional regulatory circuitries.Targeting cell cycle regulators in hematologic malignancies.Identification and Characterization of an Irreversible Inhibitor of CDK2.Designing Irreversible Inhibitors--Worth the Effort?Covalent targeting of acquired cysteines in cancerTHZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and PausingChemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations.Gdown1 Associates Efficiently with RNA Polymerase II after Promoter Clearance and Displaces TFIIF during Transcript ElongationCyclin-Dependent Kinase Inhibitors as Anticancer TherapeuticsStrategies to Inhibit Myc and Their Clinical ApplicabilityTargeting Transcription Factors in CancerDNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems PharmacologyExploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.Phorbol ester-mediated re-expression of endogenous LAT adapter in J.CaM2 cells: a model for dissecting drivers and blockers of LAT transcription.
P2860
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P2860
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@ast
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@en
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@nl
type
label
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@ast
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@en
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@nl
prefLabel
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@ast
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@en
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@nl
P2093
P2860
P356
P1433
P1476
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
@en
P2093
Anahita Dastur
Andrew P Weng
Arnaud Amzallag
Bethany Tesar
Catherine E Jenkins
Constantine S Mitsiades
Cyril H Benes
Douglas McMillin
Jarrod A Marto
Jennifer R Brown
P2860
P2888
P304
P356
10.1038/NATURE13393
P407
P577
2014-06-22T00:00:00Z