CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1
about
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genesInteraction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase IIControl of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1BCyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent mannerHuman mediator subunit MED26 functions as a docking site for transcription elongation factors7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcriptionTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsMutual relationships between transcription and pre-mRNA processing in the synthesis of mRNAGene-specific requirement of RNA polymerase II CTD phosphorylationSynthetic lethal screens as a means to understand and treat MYC-driven cancersHeterochromatin remodeling by CDK12 contributes to learning in Drosophila.The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor bThe structure and substrate specificity of human Cdk12/Cyclin KRPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylationStructure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain foldCtk1 function is necessary for full translation initiation activity in Saccharomyces cerevisiae.BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domainA positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeastCyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cellsThreonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongationRNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and TemplateNeonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition.FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor.The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress.H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFbAn inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.An investigation of a role for U2 snRNP spliceosomal components in regulating transcriptionMolecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy.Cyclin-dependent kinasesControl of transcriptional elongation.RNA polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation: A tail of two kinases.Fcp1 dephosphorylation of the RNA polymerase II C-terminal domain is required for efficient transcription of heat shock genesThe RNA polymerase II CTD coordinates transcription and RNA processing.A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation.CDK9 and H2B monoubiquitination: a well-choreographed dance.RNA polymerase II CTD modifications: how many tales from a single tail.Targeting transcription regulation in cancer with a covalent CDK7 inhibitorPol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.CDK7-dependent transcriptional addiction in triple-negative breast cancer.
P2860
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P248
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P2860
CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@ast
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@en
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@en-gb
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@nl
type
label
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@ast
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@en
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@en-gb
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@nl
prefLabel
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@ast
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@en
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@en-gb
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@nl
P2093
P2860
P921
P356
P1433
P1476
CDK12 is a transcription elong ...... etazoan ortholog of yeast Ctk1
@en
P2093
Arno L Greenleaf
Bartlomiej Bartkowiak
David H Price
Hemali P Phatnani
Jeffrey J Cooper
John T Lis
Karen Adelman
Nicholas J Fuda
Pengda Liu
P2860
P304
P356
10.1101/GAD.1968210
P407
P577
2010-10-15T00:00:00Z