Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index - Test2 - elhamkhani - TriplyDB

Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index

Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index

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Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides Peptides and Peptidomimetics for Antimicrobial Drug Design The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor Four complete turns of a curved 3₁₀-helix at atomic resolution: the crystal structure of the peptaibol trichovirin I-4A in a polar environment suggests a transition to α-helix for membrane function Rational design of alpha-helical antimicrobial peptides: do's and don'ts A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin A Fourier transformation based method to mine peptide space for antimicrobial activity.Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides.Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach.End-tagging of ultra-short antimicrobial peptides by W/F stretches to facilitate bacterial killing.Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates."Specificity Determinants" Improve Therapeutic Indices of Two Antimicrobial Peptides Piscidin 1 and Dermaseptin S4 Against the Gram-negative Pathogens Acinetobacter baumannii and Pseudomonas aeruginosa De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity.Limiting an antimicrobial peptide to the lipid-water interface enhances its bacterial membrane selectivity: a case study of MSI-367 Critical interactions in the stability control region of tropomyosin.Cell selectivity and interaction with model membranes of Val/Arg-rich peptides.Hydrophobicity and helicity regulate the antifungal activity of 14-helical β-peptides.Bacterial membrane activity of α-peptide/β-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains.Role of helicity of α-helical antimicrobial peptides to improve specificity.The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy.Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera.The role of hydrophobic amino acid grafts in the enhancement of membrane-disruptive activity of pH-responsive pseudo-peptides.Dynamics and conformational studies of TOAC spin labeled analogues of Ctx(Ile(21))-Ha peptide from Hypsiboas albopunctatus.Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.Antimicrobial and antibiofilm activity of designed and synthesized antimicrobial peptide, KABT-AMP.Rational design of α-helical antimicrobial peptides to target Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: utilization of charge, 'specificity determinants,' total hydrophobicity, hydrophobe type and location as desig Adaptive evolution of Escherichia coli to an α-peptide/β-peptoid peptidomimetic induces stable resistance.Structure-guided RP-HPLC chromatography of diastereomeric α-helical peptide analogs substituted with single amino acid stereoisomers Bacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity.Antiplasmodial properties of acyl-lysyl oligomers in culture and animal models of malaria.Synergistic interaction of PMAP-36 and PRW4 with aminoglycoside antibiotics and their antibacterial mechanism.Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides Structure-activity relationship study of novel peptoids that mimic the structure of antimicrobial peptides.Anti-tuberculosis activity of α-helical antimicrobial peptides: de novo designed L- and D-enantiomers versus L- and D-LL-37.Prokaryotic expression and mechanism of action of α-helical antimicrobial peptide A20L using fusion tags Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.

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Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index

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Rational design of alpha-helic ...... specificity/therapeutic index

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Colin T Mant

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Michael L Vasil

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Robert S Hodges

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Susan W Farmer

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Yuxin Chen

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P2860

Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor

The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains

Determination of stereochemistry stability coefficients of amino acid side-chains in an amphipathic alpha-helix.

Development of the structural basis for antimicrobial and hemolytic activities of peptides based on gramicidin S and design of novel analogs using NMR spectroscopy.

The design of Jemboss: a graphical user interface to EMBOSS.

Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes.

Animal antimicrobial peptides: an overview.

Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes.

Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity.

Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.

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12316-12329

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scholarly article

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10.1074/JBC.M413406200

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13

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280

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Robert E. W. Hancock

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2005-01-27T00:00:00Z

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15677462

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1393284

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