Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors
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A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis.The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu functionMeta-analysis to test the association of HIV-1 nef amino acid differences and deletions with disease progressionNef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex.Neuropathogenic SIVsmmFGb genetic diversity and selection-induced tissue-specific compartmentalization during chronic infection and temporal evolution of viral genes in lymphoid tissues and regions of the central nervous system.Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variableNew strain of simian immunodeficiency virus identified in wild-born chimpanzees from central Africa.HIV-1 Nef: at the crossroadsConservation of Nef function across highly diverse lineages of SIVsmm.Mechanisms of HIV-1 Nef function and intracellular signaling.Changes in the Plasticity of HIV-1 Nef RNA during the Evolution of the North American Epidemic.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses.Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice.Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.Association between a naturally arising polymorphism within a functional region of HIV-1 Nef and disease progression in chronic HIV-1 infection.Alkylating HIV-1 Nef - a potential way of HIV intervention.Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.The KT Jeang Retrovirology prize 2016: Frank Kirchhoff.Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease.The central nervous system in mucosal vaccination of rhesus macaques with simian immunodeficiency virus Deltanef.Experimental adaptive evolution of SIVcpz to pandemic HIV-1 using a humanized mouse model.
P2860
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P2860
Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Nef proteins from simian immun ...... ion of various human receptors
@ast
Nef proteins from simian immun ...... ion of various human receptors
@en
Nef proteins from simian immun ...... ion of various human receptors
@nl
type
label
Nef proteins from simian immun ...... ion of various human receptors
@ast
Nef proteins from simian immun ...... ion of various human receptors
@en
Nef proteins from simian immun ...... ion of various human receptors
@nl
prefLabel
Nef proteins from simian immun ...... ion of various human receptors
@ast
Nef proteins from simian immun ...... ion of various human receptors
@en
Nef proteins from simian immun ...... ion of various human receptors
@nl
P2093
P2860
P50
P1433
P1476
Nef proteins from simian immun ...... ion of various human receptors
@en
P2093
G Herma Renkema
Kalle Saksela
Matthias T Dittmar
Michael Schindler
Nicola Bailer
Volker Knoop
P2860
P304
P356
10.1128/JVI.78.13.6864-6874.2004
P407
P50
P577
2004-07-01T00:00:00Z