Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability
about
Twisting right to left: A…A mismatch in a CAG trinucleotide repeat overexpansion provokes left-handed Z-DNA conformationThe 26S proteasome drives trinucleotide repeat expansionsProcessing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.MutLα heterodimers modify the molecular phenotype of Friedreich ataxia.Cadmium induced cell apoptosis, DNA damage, decreased DNA repair capacity, and genomic instability during malignant transformation of human bronchial epithelial cellsR-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.Repeat instability during DNA repair: Insights from model systemsConserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.The awakening of DNA repair at Yale.The intertwined roles of transcription and repair proteins.Transcriptional consequences of XPA disruption in human cell lines.Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.R Loops and Links to Human Disease.Convergent transcription through microsatellite repeat tracts induces cell death.Replication stalling and DNA microsatellite instability.Fanconi anemia pathway regulates convergent transcription-induced cell death at trinucleotide repeats in human cells.RNA biology of disease-associated microsatellite repeat expansions.Coupling transcriptional state to large-scale repeat expansions in yeast.RNA∶DNA hybrids initiate quasi-palindrome-associated mutations in highly transcribed yeast DNA.Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae.R-loops: targets for nuclease cleavage and repeat instability.The Chromatin Remodeler Isw1 Prevents CAG Repeat Expansions During Transcription in Saccharomyces cerevisiae.Selection pressure on human STR loci and its relevance in repeat expansion disease.Genetic instability associated with loop or stem-loop structures within transcription units can be independent of nucleotide excision repair.Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy.
P2860
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P2860
Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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name
Nucleotide excision repair, mi ...... l death and repeat instability
@ast
Nucleotide excision repair, mi ...... l death and repeat instability
@en
Nucleotide excision repair, mi ...... l death and repeat instability
@nl
type
label
Nucleotide excision repair, mi ...... l death and repeat instability
@ast
Nucleotide excision repair, mi ...... l death and repeat instability
@en
Nucleotide excision repair, mi ...... l death and repeat instability
@nl
prefLabel
Nucleotide excision repair, mi ...... l death and repeat instability
@ast
Nucleotide excision repair, mi ...... l death and repeat instability
@en
Nucleotide excision repair, mi ...... l death and repeat instability
@nl
P2860
P1433
P1476
Nucleotide excision repair, mi ...... l death and repeat instability
@en
P2093
John H Wilson
P2860
P304
P356
10.1371/JOURNAL.PONE.0046807
P407
P577
2012-10-03T00:00:00Z