The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.
about
The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and diseaseTargeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?Discovering Che-1/AATF: a new attractive target for cancer therapyThe Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase MidasinInhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingPTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challengesPICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathwayPICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway.Early nucleolar disorganization in Dictyostelium cell death.Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation.Monitoring doxorubicin cellular uptake and trafficking using in vitro Raman microspectroscopy: short and long time exposure effects on lung cancer cell lines.Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell ProliferationSelective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damageGenetic control of nucleolar size: An evolutionary perspective.Tumor suppression by p53 involves inhibiting an enabler, FGF13.The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.Chromatin loops and causality loops: the influence of RNA upon spatial nuclear architecture.Probing the mechanisms underlying human diseases in making ribosomes.Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress.Crosstalk between the nucleolus and the DNA damage response.Involvement of the specific nucleolar protein SURF6 in regulation of proliferation and ribosome biogenesis in mouse NIH/3T3 fibroblasts.Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.Emerging Therapeutics to Overcome Chemoresistance in Epithelial Ovarian Cancer: A Mini-Review.Ribosome biogenesis in cancer: new players and therapeutic avenues.SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number.SNORD126 promotes HCC and CRC cell growth by activating the PI3K-AKT pathway through FGFR2.Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2.Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro-spectroscopy: binding signatures, drug resistance and DNA repair.Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why.Exploring novel key regulators in breast cancer network.Nucleolar stress: is there a reverse version?
P2860
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P2860
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.
description
2014 nî lūn-bûn
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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年学术文章
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2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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name
The nucleolus as a fundamental ...... new target for cancer therapy.
@ast
The nucleolus as a fundamental ...... new target for cancer therapy.
@en
The nucleolus as a fundamental ...... new target for cancer therapy.
@nl
type
label
The nucleolus as a fundamental ...... new target for cancer therapy.
@ast
The nucleolus as a fundamental ...... new target for cancer therapy.
@en
The nucleolus as a fundamental ...... new target for cancer therapy.
@nl
prefLabel
The nucleolus as a fundamental ...... new target for cancer therapy.
@ast
The nucleolus as a fundamental ...... new target for cancer therapy.
@en
The nucleolus as a fundamental ...... new target for cancer therapy.
@nl
P1476
The nucleolus as a fundamental ...... new target for cancer therapy.
@en
P2093
Katherine M Hannan
Simone J Woods
P304
P356
10.1016/J.BBAGRM.2014.10.007
P407
P577
2014-11-11T00:00:00Z